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Western blot analysis of lysed extracts from HT29, HeLa and 293 cells using FAK (Ab-861).
Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using FAK (Ab-861).
Western blot analysis of lysed extracts from HT29, HeLa and 293 cells using FAK (Ab-861).

FAK (Ab 861) Antibody

CATALOG NUMBER: 79-312

Clonality:
Polyclonal
Tested Applications:
IHC, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
FAK (Ab-861) antibody was raised against a peptide sequence around aa. 859~863 (H-I-Y-Q-P) derived from Human FAK.
Conjugate:
Unconjugated
Tested Applications:
IHC, WB
Application Note:
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Specificity:
This antibody detects endogenous level of total FAK protein.
Predicted Molecular Weight:
125 kDa
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality:
Polyclonal
Physical State:
Liquid
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Storage Conditions:
Store antibody at -20°C for up to one year.
Ncbi Official Symbol:
PTK2
Additional Names:
FAK, FADK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK, KIAA0288, FADK 1, PTK2
Protein Accession Number:
NP_005598.3
Protein Gi Number:
27886593
Ncbi Gene Id Number:
5747
Background:
Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity.
Background Reference 1:
Shi Q, et al. (2003) Mol Biol Cell; 14 (10): 4306-15. Vadlamudi RK, et al. (2003) FEBS Lett; 543 (1-3): 76-80. Eliceiri BP, et al. (2002) J Cell Biol Apr 01; 157 (1): 149-60. Abu-Ghazaleh R, (2001) et al. Biochem J; 360 (Pt 1): 255-64. Slack JK, et al. (2001) Oncogene; 20 (10): 1152-63.

FOR RESEARCH USE ONLY

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Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

79-312

List Size:
0.1 mg

List Price:

$370.00

Datasheet
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