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Western blot analysis of lysed extracts from HeLa cells using FAK (Ab-925).
<b>Top Image:</b> Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using FAK (Ab-925).<b>Bottom Image:</b> Immunofluorescence staining of methanol-fixed HeLa cells using FAK (Ab-925).
Western blot analysis of lysed extracts from HeLa cells using FAK (Ab-925).

FAK (Ab 925) Antibody

CATALOG NUMBER: 79-339

Clonality:
Polyclonal
Tested Applications:
IF, IHC, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
FAK (Ab-925) antibody was raised against a peptide sequence around aa.923~927 (K-V-Y-E-N) derived from Human FAK.
Conjugate:
Unconjugated
Tested Applications:
IF, IHC, WB
Application Note:
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200
Specificity:
This antibody detects endogenous level of total FAK protein.
Predicted Molecular Weight:
125 kDa
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality:
Polyclonal
Physical State:
Liquid
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Storage Conditions:
Store antibody at -20°C for up to one year.
Ncbi Official Symbol:
PTK2
Additional Names:
FAK, FADK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK, Grasp1,  FADK 1, PTK2
Protein Accession Number:
NP_005598.3
Protein Gi Number:
27886593
Ncbi Gene Id Number:
5747
Background:
Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity.
Background Reference 1:
Sanders MA, et al. (2005) J Biol Chem; 280 (25): 23516-22. Cherubini A, et al. (2005) Mol Biol Cell; 16 (6): 2972-83. Toriumi Y, et al. (2003) FEBS Lett; 553 (3): 419-22. Shi Q, et al. (2003) Mol Biol Cell; 14 (10): 4306-15.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

79-339

List Size:
0.1 mg

List Price:

$370.00

Datasheet
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