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Western blot analysis of FAM193B in Jurkat cell lysate with FAM193B antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
Immunofluorescence of FAM193B in Jurkat cells with FAM193B antibody at 20 μg/mL.
Western blot analysis of FAM193B in Jurkat cell lysate with FAM193B antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
Trial Size

FAM193B Antibody

CATALOG NUMBER: 6941

Clonality:
Polyclonal
Tested Applications:
ELISA, IF, WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Homology:
Predicted species reactivity based on immunogen sequence: Bovine: (100%), Mouse: (81%)
Immunogen:
FAM193B antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human FAM193B.
The immunogen is located within amino acids 120 - 170 of FAM193B.
Conjugate:
Unconjugated
Tested Applications:
ELISA, IF, WB
Application Note:
FAM193B antibody can be used for detection of FAM193B by Western blot at 1 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Specificity:
At least two isoforms of FAM193B are known to exist; this antibody will detect both isoforms.
Positive Control 1:
Cat. No. 1205 - Jurkat Cell Lysate
Positive Control 2:
Cat. No. 17-005 - Jurkat Cell Slide
Predicted Molecular Weight:
99 kDa
Purification:
FAM193B Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
FAM193B Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
FAM193B antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
FAM193B
Additional Names:
FAM193B Antibody: IRIZIO, KIAA1931, Protein FAM193B
Protein Accession Number:
Q96PV7
Protein Gi Number:
205831282
Ncbi Gene Id Number:
54540
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
FAM193B Antibody: FAM193B, also known as IRIZIO, was initially identified as a protein that is upregulated in alveolar rhabdomyosarcoma (ARMS), a type of fast-growing tumor characterized by chromosomal translocations fusing the PAX3 or PAX7 gene with that of FOXO1. It has been suggested that, in addition to the PAX3-FOXO1 gene fusion, disruption of the Rb and p53 pathways is required for full ARMS tumorigenesis. In PAX3-FOXO1-expressing primary mouse fibroblasts that possessed a defective p53 pathway, FAM193B expression enabled the tumorigenic transformation, suggesting that FAM193B may contribute to rhabdomyosarcomagenesis in humans.
Background Reference 1:
Picchione F, Pritchard C, Lagutina I, et al. IRIZIO: a novel gene cooperating with PAX3-FOXO1 in alveolar rhabdomyosarcoma (ARMS). Carcinogenesis 2011; 32:452-62.
Background Reference 2:
Linardic CM. PAX3-FOXO1 fusion gene in rhabdomyosarcoma. Cancer Lett. 2008; 270:10-8.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

6941

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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