Start Your Project

🛍️Explore our Promotions page to discover current deals, limited-time offers, and more!🌟

Western blot analysis in ZR-75-1 cell line lysates (35ug/lane).
Western blot analysis in ZR-75-1 cell line lysates (35ug/lane).

FBXW4 Antibody

CATALOG NUMBER: 60-930

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
This FBXW4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 341-370 amino acids from the C-terminal region of human FBXW4.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
46 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
FBXW4
Additional Names:
F-box/WD repeat-containing protein 4, Dactylin, F-box and WD-40 domain-containing protein 4, FBXW4, FBW4, SHFM3
Protein Accession Number:
P57775
Protein Gi Number:
13124191
Ncbi Gene Id Number:
6468
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
This gene is a member of the F-box/WD-40 gene family,which recruit specific target proteins through their WD-40protein-protein binding domains for ubiquitin mediated degradation.In mouse, a highly similar protein is thought to be responsible formaintaining the apical ectodermal ridge of developing limb buds;disruption of the mouse gene results in the absence of centraldigits, underdeveloped or absent metacarpal/metatarsal bones andsyndactyly. This phenotype is remarkably similar to splithand-split foot malformation in humans, a clinically heterogeneouscondition with a variety of modes of transmission. An autosomalrecessive form has been mapped to the chromosomal region where thisgene is located, and complex rearrangements involving duplicationsof this gene and others have been associated with the condition. Apseudogene of this locus has been mapped to one of the introns ofthe BCR gene on chromosome 22.
Background Reference 1:
Everman, D.B., et al. Am. J. Med. Genet.140(13):1375-1383(2006)
Background Reference 2:
Kano, H., et al. Hum. Genet. 118 (3-4), 477-483 (2005) :
Background Reference 3:
Kang, Y.S., et al. Mol. Cells 17(3):397-403(2004)
Background Reference 4:
Deloukas, P., et al. Nature 429(6990):375-381(2004)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

60-930

List Size:
400 ul

List Price:

$495.00

Datasheet
Shipping Info

$65 Standard Overnight flat rate for as many products shipped within the United States.

$35 Dry Ice Shipment fee may be required on some items.

Note: Online orders only accepted for shipment within the USA. Click here for the list of international distributors.

Customize your order

Bulk Pricing Available

Custom Formulations: azide free, endotoxin testing & endotoxin removal.

Pair your antibody with a Lysate, Peptide, Control, & /OR Secondary Antibody.

Contact our Customer Care Team for more information

Custom Antibody Services

Speak to one of our custom antibody specialists to discuss your next custom antibody project.

New & Featured Products

HIV-1 p24 Antibody [9D2F6] (HRP)
HIV-1 p24 Antibody [9D2F6] (HRP)

CATALOG NUMBER: PM-7369-HRP

HIV-1 p24 Antibody [9D2F6] (biotin)
HIV-1 p24 Antibody [9D2F6] (biotin)

CATALOG NUMBER: PM-7369-biotin

HIV-1 p24 Antibody [9D2F6]
HIV-1 p24 Antibody [9D2F6]

CATALOG NUMBER: PM-7369