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Western blot analysis in 293 cell line lysates (35ug/lane).
Western blot analysis of FDPS using rabbit polyclonal FDPS Antibody using 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the FDPS gene.
Western blot analysis in 293 cell line lysates (35ug/lane).

FDPS Antibody

CATALOG NUMBER: 58-051

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
This FDPS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 54-82 amino acids from the N-terminal region of human FDPS.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
48 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
FDPS
Additional Names:
Farnesyl pyrophosphate synthase, FPP synthase, FPS, (2E,6E)-farnesyl diphosphate synthase, Dimethylallyltranstransferase, Farnesyl diphosphate synthase, Geranyltranstransferase, FDPS, FPS, KIAA1293
Protein Accession Number:
P14324
Protein Gi Number:
215274250
Ncbi Gene Id Number:
2224
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
This gene encodes an enzyme that catalyzes the productionof geranyl pyrophosphate and farnesyl pyrophosphate fromisopentenyl pyrophosphate and dimethylallyl pyrophosphate. Theresulting product, farnesyl pyrophosphate, is a key intermediate incholesterol and sterol biosynthesis, a substrate for proteinfarnesylation and geranylgeranylation, and a ligand or agonist forcertain hormone receptors and growth receptors. Drugs that inhibitthis enzyme prevent the post-translational modifications of smallGTPases and have been used to treat diseases related to boneresorption. Multiple pseudogenes have been found on chromosomes 1,7, 14, 15, 21 and X. Multiple transcript variants encodingdifferent isoforms have been found for this gene.
Background Reference 1:
Ishimoto, K., et al. Biochem. J. 429(2):347-357(2010)
Background Reference 2:
Choi, H.J., et al. Yonsei Med. J. 51(2):231-238(2010)
Background Reference 3:
Li, J., et al. J. Immunol. 182(12):8118-8124(2009)
Background Reference 4:
Romanelli, M.G., et al. Genomics 93(3):227-234(2009)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

58-051

List Size:
400 ul

List Price:

$495.00

Datasheet
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