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FGF-23 Recombinant Protein

CATALOG NUMBER: 90-115

Specifications
source-species:
HEK293 cells
Species:
Human
source-species:
HEK293 cells
Recombinant Protein Sequence:
Signal peptide and human FGF-23 (aa 1-251) are fused at the C-terminus to the Fc portion of human IgG1.
Fusion Tag:
Fc Tag
Application Note:
This recombinant proteins is for research use only.
Biological Activity:
Activates ERK and FRS2alpha phosphorylation in Klotho expressing cells.
Purity:
>90% (SDS-PAGE).

Endotoxin level is less than 0.1EU/ μg purified protein (LAL test; Lonza).
physical-state:
Liquid
Buffer:
0.2um-filtered solution in PBS.
Concentration:
1mg/ml
Storage Conditions:
Working aliquots are stable for up to 3 months when stored at -20°C.
Ncbi Official Symbol:
FGF23
Additional Names:
Fibroblast Growth Factor 23, Tumor-derived Hypophosphatemia-inducing Factor
Protein Accession Number:
Q9GZV9
Protein Gi Number:
10190674
Ncbi Gene Id Number:
8074
Background:
FGF-23 (Fibroblast growth factor 23) is a regulator of phosphate homeostasis. It upregulates EGR1 expression in the presence of KLBy. Acts directly on the parathyroid to decrease PTH secretion. Regulates the vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization. Defects in FGF-23 are the cause of autosomal dominant hypophosphataemic rickets (ADHR) and of hyperphosphatemic familial tumoral calcinosis (HFTC).

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

90-115

List Size:
10 ug

List Price:

$328.00

Datasheet
Shipping Info

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