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The purity of rh-aFGF was determined by DTT-reduced (+) SDS-PAGE and staining overnight with Coomassie Blue.
The purity of rh-aFGF was determined by DTT-reduced (+) SDS-PAGE and staining overnight with Coomassie Blue.

FGF1 Recombinant Protein

CATALOG NUMBER: 96-016

Tested Applications:
WB
Specifications
source-species:
E. coli
Species:
Human
source-species:
E. coli
Recombinant Protein Sequence:
Phe 16 - Asp 155
Fusion Tag:
Tag free
Tested Applications:
WB
Application Note:
This recombinant protein can be used for WB. For research use only.
Predicted Molecular Weight:
15.8 kDa
Biological Activity:
The bioactivity of rh-aFGF protein was determined in a BALB/c 3T3 mouse fibroblasts cell proliferation assay. The ED50 of each lot is between 50-200 pg/mL.
Purity:
>98% as determined by SDS-PAGE.
physical-state:
Lyophilized
Buffer:
PBS, pH7.4
Storage Conditions:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Ncbi Official Symbol:
FGF1
Additional Names:
FGF1, AFGF, ECGF, ECGF-beta, ECGFA, ECGFB, FGF-alpha, FGFA, GLIO703, HBGF1
Protein Accession Number:
NP_000791
Ncbi Gene Id Number:
2246
Background:
Heparin-binding growth factor 1 is a protein that in humans is encoded by the FGF1 gene. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF acidic is a potent growth factor for fibroblasts and endothelial cells. FGF acidic is involved in wound repair, angiogenesis, and development. FGF acidic is secreted from cells via an endoplasmic reticulum/Golgi independent mechanism. The ability of FGF acidic to bind to heparin sulfate is required for its ability to interact with FGF receptors and induce signaling. There are four distinct FGF receptors and each has multiple splice variants. FGF acidic binds with high affinity to many, but not all, FGFRs. Signaling cascades activated through FGF basic binding to FGFR include the ras-raf-MAPK, PLCγ/PKC, and PI3K/Akt pathways.
Background Reference 1:
Powers, C.J. et al., 2000, Endocr Relat Cancer 7, 165-97.
Background Reference 2:
Prudovsky, I. et al., 2003, J Cell Sci 116, 4871-81.
Background Reference 3:
Ornitz, D.M. and Itoh, N., 2001, Genome Biol 2, REVIEWS3005.
Background Reference 4:
Mohammadi, M. et al., 2005, Curr Opin Struct Biol 15, 506-16.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

96-016

List Size:
0.2 mg

List Price:

$370.00

Datasheet
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