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Western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the detected the FH protein (arrow).
Western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the detected the FH protein (arrow).

FH Antibody

CATALOG NUMBER: 59-859

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Homology:
Predicted species reactivity based on immunogen sequence: Monkey, Mouse, Pig, Rat
Immunogen:
This FH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 107-135 amino acids from the N-terminal region of human FH.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
55 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
physical-state:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
FH
Additional Names:
Fumarate hydratase, mitochondrial, Fumarase, FH
Protein Accession Number:
P07954
Protein Gi Number:
1730117
Ncbi Gene Id Number:
2271
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The protein encoded by this gene is an enzymatic componentof the tricarboxylic acid (TCA) cycle, or Krebs cycle, andcatalyzes the formation of L-malate from fumarate. It exists inboth a cytosolic form and an N-terminal extended form, differingonly in the translation start site used. The N-terminal extendedform is targeted to the mitochondrion, where the removal of theextension generates the same form as in the cytoplasm. It issimilar to some thermostable class II fumarases and functions as ahomotetramer. Mutations in this gene can cause fumarase deficiencyand lead to progressive encephalopathy.
Background Reference 1:
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)
Background Reference 2:
Allegri, G., et al. J. Inherit. Metab. Dis. 33(4):411-419(2010)
Background Reference 3:
Yogev, O., et al. PLoS Biol.(3), E1000328 (2010) :
Background Reference 4:
Yang, Y., et al. Cancer Genet. Cytogenet. 196(1):45-55(2010)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

59-859

List Size:
400 ul

List Price:

$495.00

Datasheet
Shipping Info

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