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Western blot analysis in Jurkat cell line lysates (35ug/lane).
Western blot analysis in mouse kidney tissue lysates (35ug/lane).
Western blot analysis in Jurkat cell line lysates (35ug/lane).

FIG4 Antibody

CATALOG NUMBER: 59-674

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Immunogen:
This FIG4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 846-874 amino acids from the C-terminal region of human FIG4.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
104 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
FIG4
Additional Names:
Polyphosphoinositide phosphatase, 313-, Phosphatidylinositol 3,5-bisphosphate 5-phosphatase, SAC domain-containing protein 3, FIG4, KIAA0274, SAC3
Protein Accession Number:
Q92562
Protein Gi Number:
2497367
Ncbi Gene Id Number:
9896
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The protein encoded by this gene belongs to the SACdomain-containing protein gene family. The SAC domain,approximately 400 amino acids in length and consisting of sevenconserved motifs, has been shown to possess phosphoinositidephosphatase activity. The yeast homolog, Sac1p, is involved in theregulation of various phosphoinositides, and affects diversecellular functions such as actin cytoskeleton organization, Golgifunction, and maintenance of vacuole morphology. Membrane-boundphosphoinositides function as signaling molecules and play a keyrole in vesicle trafficking in eukaryotic cells. Mutations in thisgene have been associated with Charcot-Marie-Tooth disease, type4J.
Background Reference 1:
Ikonomov, O.C., et al. J. Biol. Chem. 285(35):26760-26764(2010)
Background Reference 2:
Tsai, C.P., et al. Neurobiol. Aging (2010) In press :
Background Reference 3:
Ikonomov, O.C., et al. J. Biol. Chem. 284(51):35794-35806(2009)
Background Reference 4:
Soranzo, N., et al. Nat. Genet. 41(11):1182-1190(2009)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

59-674

List Size:
400 ul

List Price:

$495.00

Datasheet
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