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FLT3 Ligand Recombinant Protein

CATALOG NUMBER: 90-300

Specifications
source-species:
CHO cells
Species:
Human, Mouse
source-species:
CHO cells
Recombinant Protein Sequence:
The receptor-binding domain of human FLT3L is fused at the N-terminus to the Fc portion of human IgG1.
Fusion Tag:
Fc Tag
Application Note:
This recombinant proteins is for research use only.
Biological Activity:
In vitro and in vivo generation of conventional and plasmacytoid dendritic cells (DC).FLT3L increases in vivo both NK and DC cells numbers in the spleen when mice are injected intraperitoneally with 2 or 10 ug, daily for 10 days (slightly higher effect at 10 ug).
Purity:
>95% (SDS-PAGE).

Endotoxin level is less than 0.1EU/ μg purified protein (LAL test; Lonza).
physical-state:
Liquid
Buffer:
In PBS (sterile).
Concentration:
1mg/ml
Storage Conditions:
Stable for at least 6 months after receipt when stored at -20°C.
Ncbi Official Symbol:
FLT3LG
Additional Names:
FMS-like Tyrosine Kinase 3 Ligand
Protein Accession Number:
P49771
Protein Gi Number:
1706818
Ncbi Gene Id Number:
2323
Background:
FMS-like tyrosine kinase 3 ligand (FLT3L) acts as a growth factor that increases the number of immune cells (lymphocytes (B cells and T cells)) by activating the hematopoietic progenitors. It binds to FLT3 (CD135) which is found on multipotent progenitor (MPP) and common lymphoid progenitor (CLP) cells in mice. FLT3L induces the mobilization of the hematopoietic progenitors and stem cells in vivo which may help the system to kill cancer cells. FLT3L is crucial for steady-state pDC (plasmacytoid dendritic cells) and cDC (classical dendritic cells) development. Deficiency of FLT3L causes a dramatic decrease in DC numbers, whereas increasing its availability increase in DC numbers.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

90-300

List Size:
10 ug

List Price:

$391.00

Datasheet
Shipping Info

$65 Standard Overnight flat rate for as many products shipped within the United States.

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