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Western blot analysis of FMR1 in rat brain tissue lysate with FMR1 antibody at 1 μg/ml.
Immunohistochemistry of FMR1 in human brain tissue with FMR1 antibody at 2.5 μg/mL.
Immunofluorescence of FMR1 in human brain tissue with FMR1 antibody at 20 μg/mL.
Western blot analysis of FMR1 in rat brain tissue lysate with FMR1 antibody at 1 μg/ml.
Trial Size

FMR1 Antibody

CATALOG NUMBER: 7707

Clonality:
Polyclonal
Tested Applications:
ELISA, IF, IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
FMR1 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human FMR1.
The immunogen is located within the last 50 amino acids of FMR1.
Conjugate:
Unconjugated
Tested Applications:
ELISA, IF, IHC-P, WB
Application Note:
FMR1 antibody can be used for detection of FMR1 by Western blot at 1 - 2 μg/ml. Antibody can also be used for Immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Specificity:
FMR1 antibody is human, mouse and rat reactive. Multiple isoforms of FMR1 are known to exist.
Positive Control 1:
Cat. No. 1463 - Rat Brain Tissue Lysate
Positive Control 2:
Cat. No. 10-301 - Human Brain Tissue Slide
Predicted Molecular Weight:
Predicted: 70 kDa
Observed: 74 kDa
Purification:
FMR1 antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
FMR1 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
FMR1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Ncbi Official Symbol:
FMR1
Additional Names:
FMR1 Antibody: Fragile X mental retardation protein 1, FMRP
Protein Accession Number:
NP_002015
Protein Gi Number:
4503765
Ncbi Gene Id Number:
2332
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Fragile X syndrome is a frequent form of inherited mental retardation caused by functional loss of the fragile X mental retardation protein, FMR1, also known as FMRP (1). FMR1 binds RNA and is associated with polysomes. The encoded protein may be involved in mRNA trafficking from the nucleus to the cytoplasm (2). A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome (1). Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1) (3).
Background Reference 1:
Jin P and Warren ST. Understanding the molecular basis of fragile X syndrome. Hum. Mol. Genet. 2000; 9:901-8.
Background Reference 2:
Corbin F, Bouillon M, Fortin A, et al. The fragile X mental retardation protein is associated with poly(A)+ mRNA in actively translating polyribosomes. Hum. Mol. Genet. 1997; 1465-72.
Background Reference 3:
Lu C, Lin L, Tan H, et al. Fragile X premutation RNA is sufficient to cause primary ovarian insufficiency in mice. Hum. Mol. Genet. 2012; 5039-47.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

7707

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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$65 Standard Overnight flat rate for as many products shipped within the United States.

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