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Western blot analysis of FNIP2 in rat skeletal muscle lysate with FNIP2 antibody at (A) 1 and (B) 2 μg/mL.
Immunohistochemistry of FNIP2 in mouse skeletal muscle tissue with FNIP2 antibody at 5 μg/mL.
Western blot analysis of FNIP2 in rat skeletal muscle lysate with FNIP2 antibody at (A) 1 and (B) 2 μg/mL.
Trial Size

FNIP2 Antibody

CATALOG NUMBER: 5045

Clonality:
Polyclonal
Tested Applications:
ELISA, IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
FNIP2 antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human FNIP2.
The immunogen is located within amino acids 860 - 910 of FNIP2.
Conjugate:
Unconjugated
Tested Applications:
ELISA, IHC-P, WB
Application Note:
FNIP2 antibody can be used for detection of FNIP2 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL.
Antibody validated: Western Blot in rat samples and Immunohistochemistry in mouse samples. All other applications and species not yet tested.
Specificity:
Multiple isoforms of FNIP2 are known to exist. This antibody is predicted to not cross-react with FNIP1.
Positive Control 1:
Cat. No. 1467 - Rat Skeletal Muscle Tissue Lysate
Purification:
FNIP2 Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
FNIP2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
FNIP2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
FNIP2
Additional Names:
FNIP2 Antibody: FNIPL, MAPO1, FNIPL, KIAA1450, Folliculin-interacting protein 2, FNIP1-like protein
Protein Accession Number:
NP_065891
Protein Gi Number:
154689769
Ncbi Gene Id Number:
57600
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
FNIP2 Antibody: FNIP2 is the second protein found to interact with folliculin, the product of the Birt-Hogg-Dube (BHD) gene. Folliculin is thought to act as a tumor suppressor as mutations or loss of heterozygosity in this gene are associated with BHD syndrome-related renal tumors. Folliculin and FNIP1, a protein that shares 49% identity to FNIP2, bind to AMPK, an important energy sensor in cells that negatively regulates the mammalian target of rapamycin (mTOR), a protein that is thought to be the master switch for cell growth and proliferation. FNIP1 and FNIP2 are able to form homo- and heteromeric multimers, suggesting these proteins may have a functional relationship.
Background Reference 1:
Hasumi H, Baba M, Hong S-B, et al. Identification and characterization of a novel folliculin-interacting protein FNIP2. Gene2008; 415:60-7.
Background Reference 2:
Takagi Y, Kobayashi T, Shiono M, et al. Interaction of folliculin (Birt-Hogg-Dube gene product) with novel Fnip1-like (FnipL/Fnip2) protein. Oncogene2008; 27:5339-47.
Background Reference 3:
Vocke CD, Yang Y, Pavlovich CP, et al. High frequency of somatic frameshift BHD mutations in Birt-Hogg-Dube-associated renal tumors. J. Natl. Cancer Inst.2005; 97:931-5.
Background Reference 4:
Baba M, Hong SB, Sharma M, et al. Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling. Proc. Natl. Acad. Sci. USA2006; 103:15552-7.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

5045

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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