FOLH1 Antibody

Background:

This gene encodes a type II transmembrane glycoproteinbelonging to the M28 peptidase family. The protein acts as aglutamate carboxypeptidase on different alternative substrates,including the nutrient folate and the neuropeptideN-acetyl-l-aspartyl-l-glutamate and is expressed in a number oftissues such as prostate, central and peripheral nervous system andkidney. A mutation in this gene may be associated with impairedintestinal absorption of dietary folates, resulting in low bloodfolate levels and consequent hyperhomocysteinemia. Expression ofthis protein in the brain may be involved in a number ofpathological conditions associated with glutamate excitotoxicity.In the prostate the protein is up-regulated in cancerous cells andis used as an effective diagnostic and prognostic indicator ofprostate cancer. This gene likely arose from a duplication event ofa nearby chromosomal region. Alternative splicing gives rise tomultiple transcript variants encoding several different isoforms.