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Human Frizzled-10, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
Human Frizzled-10, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

Frizzled-10 / FZD10 Recombinant Protein

CATALOG NUMBER: 11-179

Tested Applications:
WB
Specifications
source-species:
HEK293 cells
Species:
Human
source-species:
HEK293 cells
Recombinant Protein Sequence:
Ile 21 - Gly 161
Fusion Tag:
His Tag
Tested Applications:
WB
Application Note:
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 18.0 kDa. The protein migrates as 22-25 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Predicted Molecular Weight:
18.0 kDa
Purity:
>90% as determined by SDS-PAGE.
physical-state:
Lyophilized
Buffer:
PBS, pH7.4
Storage Conditions:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Ncbi Official Symbol:
FZD10
Additional Names:
Fz-10,FZD10,hFz10,FzE7,CD350
Protein Accession Number:
NP_009128.1
Ncbi Gene Id Number:
11211
Background:
Frizzled-10 (FZD10) is also known as FzE7 or CD350, which belongs to the G-protein coupled receptor Fz/Smo family. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. FZD10 contains one FZ (frizzled) domain. FZD10 protein is a cell surface receptor, which is activated by Wnt proteins and involved in the regulation of cellular function. FZD10 interacts with WNT7B and MYOC.
Background Reference 1:
Dorsam RT, Gutkind JS, Nat Rev Cancer. 2007 Feb; 7(2):79-94.
Background Reference 2:
Wang, Z. et al. (2005) Mol. Cell. Biol. 25:5022.
Background Reference 3:
Kwon HS, et al. Mol Cell Biol. 2009.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

11-179

List Size:
0.1 mg

List Price:

$577.00

Datasheet
Shipping Info

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