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Western blot analysis of FRL1 in EL4 cell lysate with FRL1 antibody at 1 μg/mL.
Immunofluorescence of FRL1 in EL4 cells with FRL1 antibody at 20 μg/mL.
Western blot analysis of FRL1 in EL4 cell lysate with FRL1 antibody at 1 μg/mL.
Trial Size

FRL1 Antibody

CATALOG NUMBER: 7101

Clonality:
Polyclonal
Tested Applications:
ELISA, IF, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Rabbit polyclonal FRL1 antibody was raised against a 16 amino acid peptide near the carboxy terminus of human FRL1.
The immunogen is located within the last 50 amino acids of FRL1.
Conjugate:
Unconjugated
Tested Applications:
ELISA, IF, WB
Application Note:
FRL1 antibody can be used for detection of FRL1 by Western blot at 1 - 2 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
Specificity:
FRL1 antibody is human, mouse and rat reactive. Three alternatively spliced transcript variants have been observed
Positive Control 1:
Cat. No. 1287 - EL4 Cell Lysate
Positive Control 2:
Cat. No. 17-207 - EL4 Cell Slide
Predicted Molecular Weight:
121 kDa
Purification:
FRL1 Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
FRL1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
FRL1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
FMNL1
Additional Names:
FRL1 Antibody: FMNL, FHOD4, KW-13, C17orf1, C17orf1B, FMNL, Formin-like protein 1, CLL-associated antigen KW-13
Protein Accession Number:
NP_005883
Protein Gi Number:
33356148
Ncbi Gene Id Number:
752
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
FRL1 Antibody: The Formin-like protein 1 (FRL1) gene encodes a formin-related protein which has been implicated in morphogenesis, cyokinesis, and cell polarity. Formins are a conserved class of proteins expressed in all eukaryotes and have one DAD (diaphanous autoregulatory domain), one FH2 (formin homology 2) domain and one GBD/FH3 (Rho GTPase-binding / formin homology 3) domain. FRL1 is located in the cytoplasm and is highly expressed in the spleen, lymph node and bone marrow cells. FRL1 possibly has a role in the control of cell motility, survival of macrophages and cytoskeletal organization.
Background Reference 1:
Katoh M and Katoh M. Identification and characterization of human FMNL1, FMNL2 and FMNL3 genes in silico. Int. J. Oncol. 2003; 22:1161-8.
Background Reference 2:
Yayoshi-Yamamoto S, Taniuchi I and Watanabe T. FRL, a novel formin-related protein, binds to Rac and regulates cell motility and survival of macrophages. Mol. Cell. Biol. 2000; 20: 6872-81.
Background Reference 3:
Favaro PM, Traina F, Vassallo J, et al. High expression of FMNL1 protein in T non-Hodgkin's lymphomas. Leuk. Res. 2006; 30:735-8.
Background Reference 4:
Gomez TS, Kumar K, Medeiros RB, et al. Formins regulate the actin-related protein 2/3 complex-independent polarization of the centrosome to the immunological synapse. Immunity 2007; 26:177-90.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

7101

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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