FUS Antibody

CATALOG NUMBER: 55-074

Clonality:
Polyclonal
Tested Applications:
Flow, IF, IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Homology:
Predicted species reactivity based on immunogen sequence: Bovine
Immunogen:
This FUS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 499-526 amino acids from the C-terminal region of human FUS.
Conjugate:
Unconjugated
Tested Applications:
Flow, IF, IHC-P, WB
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:50~100
For FACS starting dilution is: 1:10~50
For IF starting dilution is: 1:10~50
Predicted Molecular Weight:
53 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
FUS
Additional Names:
RNA-binding protein FUS, 75 kDa DNA-pairing protein, Oncogene FUS, Oncogene TLS, POMp75, Translocated in liposarcoma protein, FUS, TLS
Protein Accession Number:
P35637
Protein Gi Number:
544357
Ncbi Gene Id Number:
2521
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
This gene encodes a multifunctional protein component ofthe heterogeneous nuclear ribonucleoprotein (hnRNP) complex. ThehnRNP complex is involved in pre-mRNA splicing and the export offully processed mRNA to the cytoplasm. This protein belongs to theFET family of RNA-binding proteins which have been implicated incellular processes that include regulation of gene expression,maintenance of genomic integrity and mRNA/microRNA processing.Alternative splicing results in multiple transcript variants.Defects in this gene result in amyotrophic lateral sclerosis type6.
Background Reference 1:
Kim, S.H., et al. J. Biol. Chem. 285(44):34097-34105(2010)
Background Reference 2:
Mackenzie, I.R., et al. Lancet Neurol 9(10):995-1007(2010)
Background Reference 3:
Yan, J., et al. Neurology 75(9):807-814(2010)
Background Reference 4:
Waibel, S., et al. Neurology 75(9):815-817(2010)

FOR RESEARCH USE ONLY

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Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

55-074

List Size:
400 ul

List Price:

$495.00

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