FXYD5 Antibody

Background:

This gene encodes a member of a family of small membraneproteins that share a 35-amino acid signature sequence domain,beginning with the sequence PFXYD and containing 7 invariant and 6highly conserved amino acids. The approved human gene nomenclaturefor the family is FXYD-domain containing ion transport regulator.Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2,also known as the gamma subunit of the Na,K-ATPase, regulates theproperties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma),FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown toinduce channel activity in experimental expression systems.Transmembrane topology has been established for two family members(FXYD1 and FXYD2), with the N-terminus extracellular and theC-terminus on the cytoplasmic side of the membrane. This geneproduct, FXYD5, is a glycoprotein that functions in theup-regulation of chemokine production, and it is involved in thereduction of cell adhesion via its ability to down-regulateE-cadherin. It also promotes metastasis, and has been linked to avariety of cancers. Alternative splicing results in multipletranscript variants. [RefSeq curation by Kathleen J. Sweadner,Ph.D., sweadner@helix.mgh.harvard.edu.].