FZD6 Antibody

Background:

This gene represents a member of the 'frizzled' genefamily, which encode 7-transmembrane domain proteins that arereceptors for Wnt signaling proteins. The protein encoded by thisfamily member contains a signal peptide, a cysteine-rich domain inthe N-terminal extracellular region, and seven transmembranedomains, but unlike other family members, this protein does notcontain a C-terminal PDZ domain-binding motif. This proteinfunctions as a negative regulator of the canonical Wnt/beta-cateninsignaling cascade, thereby inhibiting the processes that triggeroncogenic transformation, cell proliferation, and inhibition ofapoptosis. Alternative splicing results in multiple transcriptvariants.