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Western blot analysis in mouse cerebellum tissue lysates (35ug/lane).
Western blot analysis in A549 cell line lysates (35ug/lane).
GABBR2 antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.
Western blot analysis in mouse cerebellum tissue lysates (35ug/lane).

GABBR2 Antibody

CATALOG NUMBER: 55-090

Clonality:
Polyclonal
Tested Applications:
IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Homology:
Predicted species reactivity based on immunogen sequence: Rat
Immunogen:
This GABBR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 861-890 amino acids from the C-terminal region of human GABBR2.
Conjugate:
Unconjugated
Tested Applications:
IHC-P, WB
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:50~100
Predicted Molecular Weight:
106 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
GABBR2
Additional Names:
Gamma-aminobutyric acid type B receptor subunit 2, GABA-B receptor 2, GABA-B-R2, GABA-BR2, GABABR2, Gb2, G-protein coupled receptor 51, HG20, GABBR2, GPR51, GPRC3B
Protein Accession Number:
O75899
Ncbi Gene Id Number:
9568
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The multi-pass membrane protein encoded by this genebelongs to the G-protein coupled receptor 3 family and GABA-Breceptor subfamily. The GABA-B receptors inhibit neuronal activitythrough G protein-coupled second-messenger systems, which regulatethe release of neurotransmitters, and the activity of ion channelsand adenylyl cyclase. This receptor subunit forms an activeheterodimeric complex with GABA-B receptor subunit 1, neither ofwhich is effective on its own. Allelic variants of this gene havebeen associated with nicotine dependence.
Background Reference 1:
Oblak, A.L., et al. J. Neurochem. 114(5):1414-1423(2010)
Background Reference 2:
Letra, A., et al. Am. J. Med. Genet.152A (7), 1701-1710 (2010) :
Background Reference 3:
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Background Reference 4:
Jugessur, A., et al. PLoS ONE(7), E11493 (2010) :

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

55-090

List Size:
400 ul

List Price:

$495.00

Datasheet
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