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Western blot testing of human 1) HT20, 2) A549, 3) HEK293 and 4) A431 cell lysate with Plakoglobin antibody (clone 11E4). Predicted molecular weight: 80-87 kDa.
Western blot testing of human 1) HT20, 2) A549, 3) HEK293 and 4) A431 cell lysate with Plakoglobin antibody (clone 11E4). Predicted molecular weight: 80-87 kDa.

Gamma Catenin Antibody [11E4.]

CATALOG NUMBER: 33-585

Clonality:
Monoclonal
Tested Applications:
IF, IP, WB
Host Species:
Mouse
Species Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Mouse
Species Reactivity:
Human, Mouse
Immunogen:
Recombinant full length human gamma Catenin fused to maltose binding protein was used as the immunogen for the Plakoglobin antibody. The epitope has been found to be in the N-terminal region.
Conjugate:
Unconjugated
Tested Applications:
IF, IP, WB
Application Note:
Immunofluorescence: 1-2 ug/ml
WB: 0.5-1 ug/ml
Immunoprecipitation: suitable
Titration of the Plakoglobin antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Purification:
Protein G affinity chromatography
Clonality:
Monoclonal
Isotype:
IgG1, kappa
physical-state:
Liquid
Buffer:
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Concentration:
0.2 mg/mL
Storage Conditions:
Aliquot and Store at 2-8°C. Avoid freez-thaw cycles.
Ncbi Official Symbol:
JUP
Additional Names:
Junction plakoglobin, Catenin gamma, Desmoplakin III, Desmoplakin-3, JUP, CTNNG, DP3
Ncbi Gene Id Number:
3728
User Note:
Optimal dilutions for each application to be determined by the researcher
Background:
It recognizes a protein of 80-87kDa, identified as gamma-Catenin or Plakoglobin. The catenins (alpha, beta, gamma and δ) are ubiquitously expressed, cytoplasmic proteins that associate with E-cadherin at cellular junctions. Catenin/cadherin complexes play an important role in mediating cellular adhesion. alpha T-catenin, also referred to as VR22, is a 895-amino acid protein that is most abundantly expressed in cardio-myocytes and in the peritubular myoid cells of the testis. alpha T-catenin binds to alpha E-catenin as well as to beta-catenin, and it functions to inhibit Wnt signaling. CTNNA3, the gene that encodes for alpha-T-catenin, is located on chromosome 10, and mutations in this gene show a strong correlation to late-onset Alzheimer s disease (LOAD) as well as to dilated cardiomyopathy.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

33-585

List Size:
100 ug

List Price:

$626.00

Datasheet
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