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Western blot of rat hippocampal homogenate showing specific immunolabeling of the~ 67k GAT-1 protein.
Western blot of rat hippocampal homogenate showing specific immunolabeling of the~ 67k GAT-1 protein.

GAT-1 Antibody

CATALOG NUMBER: 50-215

Clonality:
Polyclonal
Tested Applications:
IHC, WB
Host Species:
Rabbit
Species Reactivity:
Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Mouse, Rat
Immunogen:
Peptide corresponding to amino acid residues from the C-terminal region of rat GAT-1.
Conjugate:
Unconjugated
Tested Applications:
IHC, WB
Application Note:
The antibody has been directly tested for reactivity in Western blots with rat tissue. It is anticipated that the antibody will also react with mouse tissue based on the fact that this species has 100% homology with the amino acid sequence used as antigen.
Predicted Molecular Weight:
67
Purification:
Affinity Purified
Clonality:
Polyclonal
Physical State:
Liquid
Concentration:
batch dependent
Storage Conditions:
GAT-1 antibody can be stored at -20°C and is stable at -20°C for at least 1 year.
Ncbi Official Symbol:
Slc6a1
Protein Accession Number:
P23978
Protein Gi Number:
128609
Ncbi Gene Id Number:
79212
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl− channel associated with the GABAA receptor (GABAA-R) subtype. GABA plasma membrane transporters (GATs) influence synaptic neurotransmission by high-affinity uptake and release of GABA. To date, four distinct GABA transporters have been identified: GAT-1, GAT-2, GAT-3, and BGT-1. GAT-1, the most abundant of the transporters, is found predominantly in neurons, but also in some specialized glia (Minelli et al., 1995). GAT-1 is thought to play a key role in epileptogenesis (Zhao et al. 2003).
Background Reference 1:
Minelli A, Brecha NC, Karschin C, DeBiasi S, Conti F (1995) GAT-1, a high-affinity GABA plasma membrana transporter, is localizad to neurons and astroglia int he cerebral cortex. J. Neurosci. 15(11):7734-7746.
Background Reference 2:
Zhao WJ, Ma YH, Fei J, Mei ZT, Guo LH (2003) Increase in drug-induced seizure susceptibility of transgenic mice overexpressing GABA transporter 1. Acta Pharmacol. Sin. 24(10):991-5.

FOR RESEARCH USE ONLY

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Disclaimer:
This product is for research use only.

CATALOG NUMBER:

50-215

List Size:
0.1 mL

List Price:

$540.00

Datasheet
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