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GDF-11 Recombinant Protein

CATALOG NUMBER: 40-209

Specifications
source-species:
E. coli
Species:
Human, Mouse, Rat
source-species:
E. coli
Recombinant Protein Sequence:
NLGLDCDEHS SESRCCRYPL TVDFEAFGWD WIIAPKRYKA NYCSGQCEYM FMQKYPHTHL VQQANPRGSA GPCCTPTKMS PINMLYFNDK QQIIYGKIPG MVVDRCGCS
Biological Activity:
The ED50 was determined by its ability to inhibit alkaline phosphatase activity in differentiating MC3T3/E1 cells. The ED50 for this effect is 8-10 ng/ml.
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin level is less than 0.1 ng per μg (1EU/μg).
physical-state:
Lyophilized
Storage Conditions:
The lyophilized GDF-11 recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted GDF-11 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, exposing GDF-11 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
Ncbi Official Symbol:
GDF11
Additional Names:
BMP11, BMP-11, BMP11, Bone morphogenetic protein 11, GDF-11
Protein Accession Number:
NP_005802.1
Protein Gi Number:
5031613
Ncbi Gene Id Number:
10220
Background:
GDF-11 is a myostatin-homologous protein that acts as an inhibitor of nerve tissue growth. GDF-11 has been shown to suppress neurogenesis through a myostatin-like pathway, which involves arrest of progenitor cell-cycle in the G1 phase. Similarities between myostatin and GDF-11, which are 90% identical in their amino acid sequence, suggests that the regulatory mechanisms responsible for maintaining proper tissue size during neural and muscular development might be the same. Recombinant human GDF-11 is a 25.0 kDa disulfide-linked homodimer containing two 109 amino acid polypeptide chains. It is highly homologous to myostatin/GDF-8 sharing 90% amino-acid sequence identity.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
This product is for research use only.

CATALOG NUMBER:

40-209

List Size:
0.005 mg, 0.02 mg

List Price:

Price range: $215.00 through $323.00

Datasheet
Shipping Info

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