GGCX Antibody

CATALOG NUMBER: 55-643

Clonality:
Polyclonal
Tested Applications:
IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Homology:
Predicted species reactivity based on immunogen sequence: Rat
Immunogen:
This GGCX antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 548-578 amino acids from the Central region of human GGCX.
Conjugate:
Unconjugated
Tested Applications:
IHC-P, WB
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:50~100
Predicted Molecular Weight:
88 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
GGCX
Additional Names:
Vitamin K-dependent gamma-carboxylase, Gamma-glutamyl carboxylase, Peptidyl-glutamate 4-carboxylase, Vitamin K gamma glutamyl carboxylase, GGCX, GC
Protein Accession Number:
P38435
Protein Gi Number:
84028279
Ncbi Gene Id Number:
2677
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
This gene encodes an enzyme which catalyzes theposttranslational modification of vitamin K-dependent protein. Manyof these vitamin K-dependent proteins are involved in coagulationso the function of the encoded enzyme is essential for hemostasis.Mutations in this gene are associated with vitamin K-dependentcoagulation defect and PXE-like disorder with multiple coagulationfactor deficiency. Multiple transcript variants encoding differentisoforms have been found for this gene.
Background Reference 1:
Higgins-Gruber, S.L., et al. J. Biol. Chem. 285(41):31502-31508(2010)
Background Reference 2:
King, C.R., et al. Thromb. Haemost. 104(4):750-754(2010)
Background Reference 3:
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Background Reference 4:
Ikejiri, M., et al. Int. J. Hematol. 92(2):302-305(2010)

FOR RESEARCH USE ONLY

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Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

55-643

List Size:
400 ul

List Price:

$495.00

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