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IHC testing of FFPE human pancreas with GP2 antibody (clone GP2/1712). HIER: boil tissue sections in 10mM Tris with 1mM EDTA, pH 9, for 10-20 min.
IHC testing of FFPE human pancreas with GP2 antibody (clone GP2/1712). HIER: boil tissue sections in 10mM Tris with 1mM EDTA, pH 9, for 10-20 min.

Glycoprotein 2 Antibody [GP2/1712]

CATALOG NUMBER: 33-696

Clonality:
Monoclonal
Tested Applications:
Flow, IF, IHC-P
Host Species:
Mouse
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Mouse
Species Reactivity:
Human
Immunogen:
A partial human recombinant protein corresponding to amino acids 35-179 was used as the immunogen for the GP2 antibody.
Conjugate:
Unconjugated
Tested Applications:
Flow, IF, IHC-P
Application Note:
Flow Cytometry: 0.5-1ug/10e6 cells in 0.1ml
Immunofluorescence: 0.5-1 ug/ml
IHC (FFPE): 1-2 ug/ml for 30 min at RT
Optimal dilution of the GP2 antibody should be determined by the researcher.
Specificity:
Does not react with Mouse
Purification:
Protein G affinity chromatography
Clonality:
Monoclonal
Isotype:
IgG2b, lambda
Physical State:
Liquid
Buffer:
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Concentration:
0.2 mg/mL
Storage Conditions:
Aliquot and Store at 2-8°C. Avoid freez-thaw cycles.
Ncbi Official Symbol:
GP2
Additional Names:
Pancreatic secretory granule membrane major glycoprotein GP2, Pancreatic zymogen granule membrane protein GP-2, ZAP75, GP2
Ncbi Gene Id Number:
2813
User Note:
Optimal dilutions for each application to be determined by the researcher
Background:
GP2 (Glycoprotein 2), also known as ZAP75, is a 537 amino acid secreted protein. It is an integral membrane protein that is secreted from intracellular zymogen granules and associates with the plasma membrane via glycosylphosphatidylinositol (GPI) linkage. GP2 is cleaved and then released into the pancreatic duct along with exocrine secretions. GP2 binds pathogens such as enterobacteria, thereby playing an important role in the innate immune response. The C-terminus of this protein is related to the C-terminus of the protein encoded by the neighboring gene, uromodulin (UMOD). GP2 is also expressed on the apical plasma membrane of specialized microfold (M) cells among enterocytes and serves as a transcytotic receptor for mucosal antigens. M cells are considered a promising target for oral vaccination against various infectious diseases.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

33-696

List Size:
100 ug

List Price:

$626.00

Datasheet
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