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Human Glypican 2, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
Human Glypican 2, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

Glypican 2 / GPC2 Recombinant Protein

CATALOG NUMBER: 11-254

Tested Applications:
WB
Specifications
Source Species:
HEK293 cells
Species:
Human
Source Species:
HEK293 cells
Recombinant Protein Sequence:
Ser 24 - Ser 553
Fusion Tag:
Fc Tag
Tested Applications:
WB
Application Note:
This protein carries a human IgG1 Fc tag at the C-terminus.This protein contains a furin cleavage site, 355-RNRR-358, and will be processed into N and C-terminal fragment with calculated MW of 37.3 kDa and 47.3 kDa respectively. The N and C-terminal frag
Predicted Molecular Weight:
37.3 kDa & 47.3 kDa
Purity:
>95% as determined by SDS-PAGE.
Physical State:
Lyophilized
Buffer:
Tris with Glycine, Arginine and NaCl, pH7.5
Storage Conditions:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Ncbi Official Symbol:
GPC2
Additional Names:
Glypican 2,GPC2
Protein Accession Number:
NP_689955.1
Ncbi Gene Id Number:
221914
Background:
Glypican 2 (GPC2), also known cerebroglycan, is a glycophosphatidylinositol-linked integral membrane heparan sulfate proteoglycan found in the developing nervous system. Cerebroglycan participates in cell adhesion and is thought to regulate the growth and guidance of axons. Cerebroglycan has especially high affinity for laminin-1. GPC2 silencing inactivates Wnt/β-catenin signaling and reduces the expression of N-Myc, an oncogenic driver of neuroblastoma tumorigenesis. Immunotoxins and chimeric antigen receptor (CAR) T cells targeting GPC2 inhibit neuroblastoma growth in mouse models. A GPC3 specific antibody drug conjugate (ADC) can also inhibit neuroblastoma cell proliferation.
Background Reference 1:
Herndon ME, et al. 1999. Glycobiology. 9(2):143-55.
Background Reference 2:
Li N, et al. 2017. Proc Natl Acad Sci U S A. 114(32):E6623-E6631.
Background Reference 3:
Bosse KR, et al. 2017. Cancer Cell. 32(3):295-309.

FOR RESEARCH USE ONLY

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Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

11-254

List Size:
0.1 mg

List Price:

$577.00

Datasheet
Shipping Info

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