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Western blot analysis of lysate from human ovary tissue lysate, using GNRHR Antibody at 1:1000 at each lane.
Western blot analysis of lysate from human ovary tissue lysate, using GNRHR Antibody at 1:1000 at each lane.

GNRHR Antibody

CATALOG NUMBER: 59-795

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
This GNRHR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 49-77 amino acids from the N-terminal region of human GNRHR.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
38 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
GNRHR
Additional Names:
Gonadotropin-releasing hormone receptor, GnRH receptor, GnRH-R, GNRHR, GRHR
Protein Accession Number:
P30968
Protein Gi Number:
399777
Ncbi Gene Id Number:
2798
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
This gene encodes the receptor for type 1gonadotropin-releasing hormone. This receptor is a member of theseven-transmembrane, G-protein coupled receptor (GPCR) family. Itis expressed on the surface of pituitary gonadotrope cells as wellas lymphocytes, breast, ovary, and prostate. Following binding ofgonadotropin-releasing hormone, the receptor associates withG-proteins that activate a phosphatidylinositol-calcium secondmessenger system. Activation of the receptor ultimately causes therelease of gonadotropic luteinizing hormone (LH) and folliclestimulating hormone (FSH). Defects in this gene are a cause ofhypogonadotropic hypogonadism (HH). Alternative splicing results inmultiple transcript variants encoding different isoforms. More than18 transcription initiation sites in the 5' region and multiplepolyA signals in the 3' region have been identified for this gene.
Background Reference 1:
Canzian, F., et al. Hum. Mol. Genet. 19(19):3873-3884(2010)
Background Reference 2:
Armstrong, S.P., et al. J. Biol. Chem. 285(32):24360-24371(2010)
Background Reference 3:
Lee, G., et al. Cancer Immunol. Immunother. 59(7):1011-1019(2010)
Background Reference 4:
Re, M., et al. PLoS ONE(7), E11489 (2010) :

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

59-795

List Size:
400 ul

List Price:

$495.00

Datasheet
Shipping Info

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