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Western blot analysis of extracts from Jurkat cells treated with EGF using Phospho-GR (Ser226) Antibody. The lane on the right is treated with the antigen-specific peptide.
Western blot analysis of extracts from Jurkat cells treated with EGF using Phospho-GR (Ser226) Antibody. The lane on the right is treated with the antigen-specific peptide.

GR (phospho Ser226) Antibody

CATALOG NUMBER: 79-987

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
GR (phospho Ser226) antibody was raised against a peptide sequence around phosphorylation site of serine 226 (L-L-S (p)-P-L) derived from Human GR.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
Western Blot: 1:500~1:1000
Specificity:
The antibody detects endogenous level of GR only when phosphorylated at serine 226.
Predicted Molecular Weight:
86 kDa
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality:
Polyclonal
Isotype:
IgG
Physical State:
Liquid
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Storage Conditions:
Store antibody at -20°C for up to one year.
Ncbi Official Symbol:
NR3C1
Additional Names:
GCCR, GCR, GRL;, NR3C1,
Protein Accession Number:
NP_000167.1
Protein Gi Number:
4504133
Ncbi Gene Id Number:
2908
Background:
Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation.
Background Reference 1:
Wehmeyer L, Du Toit A, Lang DM, Hapgood JP (2014) J Biol Chem 289, 10235-51
Background Reference 2:
Bouazza B, et al. (2014) Am J Respir Cell Mol Biol 50, 301-15
Background Reference 3:
Lee MS, et al. (2013) Behav Brain Res 236, 56-61

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

79-987

List Size:
0.1 mg

List Price:

$355.00

Out of stock

Datasheet
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