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Immobilized Human BMP-2, Tag Free at 2 ug/mL (100 uL/well) can bind Human Gremlin, Fc Tag with a linear range of 0.8-80 ng/mL.
Immobilized Human BMP-2, Tag Free at 2 ug/mL (100 uL/well) can bind Human Gremlin, Fc Tag with a linear range of 0.8-80 ng/mL.

Gremlin Recombinant Protein

CATALOG NUMBER: 96-881

Tested Applications:
ELISA, WB
Specifications
source-species:
HEK293 cells
Species:
Human
source-species:
HEK293 cells
Recombinant Protein Sequence:
Lys 25 - Asp 184
Fusion Tag:
Fc Tag
Tested Applications:
ELISA, WB
Application Note:
This recombinant protein can be used for E, WB. For research use only.
Predicted Molecular Weight:
44.2 kDa
Biological Activity:
Measured by its binding ability in a functional ELISA. Immobilized Human BMP-2, Tag Free at 2 ug/mL (100 uL/well) can bind Human Gremlin, Fc Tag with a linear range of 0.8-80 ng/mL.
Purity:
>95% as determined by SDS-PAGE.

Endotoxin level is less than 1.0 EU per ug by the LAL method.
physical-state:
Lyophilized
Buffer:
50 mM Tris, 150 mM NaCl, pH7.5 with 1 mM EDTA
Storage Conditions:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Ncbi Official Symbol:
Gremlin
Additional Names:
GREM1,CKTSF1B1,DAND2,DRM,PIG2
Protein Accession Number:
NP_037504
Ncbi Gene Id Number:
26585
Background:
Gremlin is also known as Cysteine knot superfamily 1, BMP antagonist 1 (CKTSF1B1), DAN domain family member 2 (DAND2), Down-regulated in Mos-transformed cells protein (DRM), Increased in high glucose protein 2 (IHG-2), Cell proliferation-inducing gene 2 protein (PIG2) or Gremlin-1 (GREM1), which is highly expressed in small intestine, fetal brain and colon. Gremlin / GREM-1 interacts with SLIT1 and SLIT2 in a glycosylation-dependent manner. Gremlin may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Gremlin down-regulates the BMP4 signaling in a dose-dependent manner and acts as inhibitor of monocyte chemotaxis.
Background Reference 1:
McMahon R., et al., 2000, J. Biol. Chem. 275:9901-9904.
Background Reference 2:
Topol L.Z., et al., 2000, Cytogenet. Cell Genet. 89:79-84.
Background Reference 3:
Jaeger E., et al., 2012, Nat. Genet. 44:699-703.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

96-881

List Size:
0.1 mg

List Price:

$515.00

Datasheet
Shipping Info

$65 Standard Overnight flat rate for as many products shipped within the United States.

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