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Western blot analysis of GRINA in human testis tissue lysate with GRINA antibody at (A) 1 and (B) 2 μg/mL.
Western blot analysis of GRINA in human testis tissue lysate with GRINA antibody at (A) 1 and (B) 2 μg/mL.
Trial Size

GRINA Antibody

CATALOG NUMBER: 7147

Clonality:
Polyclonal
Tested Applications:
ELISA, WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Homology:
Predicted species reactivity based on immunogen sequence: Mouse: (94%), Rat: (94%), Bovine: (83%)
Immunogen:
Rabbit polyclonal GRINA antibody was raised against an 18 amino acid peptide near the center of human GRINA.
The immunogen is located within amino acids 110 - 160 of GRINA.
Conjugate:
Unconjugated
Tested Applications:
ELISA, WB
Application Note:
GRINA antibody can be used for detection of GRINA by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Specificity:
GRINA antibody is predicted to not cross-react with other members of the TMBIM family.
Positive Control 1:
Cat. No. 1313 - Human Testis Tissue Lysate
Predicted Molecular Weight:
Predicted: 41 kDa
Purification:
GRINA Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
GRINA Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
GRINA antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Ncbi Official Symbol:
GRINA
Additional Names:
GRINA Antibody: LFG1, HNRGW, TMBIM3, NMDARA1, LFG1, Protein lifeguard 1, NMDA receptor glutamate-binding subunit
Protein Accession Number:
NP_001009184
Protein Gi Number:
57165375
Ncbi Gene Id Number:
2907
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
GRINA Antibody: The transmembrane BAX inhibitor motif (TMBIM) family of proteins includes the founder member TMBIM6/BI-1, TMBIM1/RECS1 (responsive to centrifugal force and shear stress gene 1 protein), TMBIM2/LFG (life guard), TMBIM3/GRINA (glutamate receptor ionotropic NMDA protein 1), TMBIM4/GAAP (Golgi anti-apoptotic-associated protein), and TMBIM5/GHTIM (growth hormone-inducible transmembrane protein). They are highly conserved in mammals and zebrafish and contain a conserved BAX inhibitor-1 motif. GRINA is expressed in the brain and is a potential apoptotic regulator.
Background Reference 1:
Yamaji T, Nishikawa K and Hanada K et al. Transmembrane BAX inhibitor motif containing (TMBIM) family proteins perturbs a trans-Golgi network enzyme, Gb3 synthase, and reduces Gb3 biosynthesis. J. Biol. Chem. 2010; 285:35505-18.
Background Reference 2:
Nielsen JA, Chambers MA, Romm E, et al. Mouse transmembrane BAX inhibitor motif 3 (Tmbim3) encodes a 38 kDa transmembrane protein expressed in the central nervous system. Mol. Cell. Biochem. 2011; 357:73-81.
Background Reference 3:
Rojas-Rivera D, Armisén R, Colombo A, et al. TMBIM3/GRINA is a novel unfolded protein response (UPR) target gene that controls apoptosis through the modulation of ER calcium homeostasis. Cell Death Differ. 2012; 19:1013-26.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

7147

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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