GRM1 Antibody

Background:

L-glutamate is the major excitatory neurotransmitter inthe central nervous system and activates both ionotropic andmetabotropic glutamate receptors. Glutamatergic neurotransmissionis involved in most aspects of normal brain function and can beperturbed in many neuropathologic conditions. The metabotropicglutamate receptors are a family of G protein-coupled receptors,that have been divided into 3 groups on the basis of sequencehomology, putative signal transduction mechanisms, andpharmacologic properties. Group I includes GRM1 and GRM5 and thesereceptors have been shown to activate phospholipase C. Group IIincludes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7and GRM8. Group II and III receptors are linked to the inhibitionof the cyclic AMP cascade but differ in their agonistselectivities. The canonical alpha isoform of the metabotropicglutamate receptor 1 gene is a disulfide-linked homodimer whoseactivity is mediated by a G-protein-coupledphosphatidylinositol-calcium second messenger system. Alternativesplicing results in multiple transcript variants encoding distinctisoforms; some of which may have distinct functions. [provided byRefSeq].