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The purity of rh GHR was determined by DTT-reduced (+) SDS-PAGE and staining overnight with Coomassie Blue.
The purity of rh GHR was determined by DTT-reduced (+) SDS-PAGE and staining overnight with Coomassie Blue.

Growth Hormone Receptor Recombinant Protein

CATALOG NUMBER: 96-350

Tested Applications:
WB
Specifications
source-species:
HEK293 cells
Species:
Human
source-species:
HEK293 cells
Recombinant Protein Sequence:
Ala 27 - Tyr 264
Fusion Tag:
His Tag
Tested Applications:
WB
Application Note:
This recombinant protein can be used for WB. For research use only.
Predicted Molecular Weight:
28.5 kDa
Biological Activity:
Immobilized Human GH, Tag Free at 2ug/mL (100uL/well) can bind Human GHR, His Tag with a linear range of 1-7.8 ng/mL.
Purity:
>95% as determined by SDS-PAGE.
physical-state:
Lyophilized
Buffer:
PBS, pH7.4
Storage Conditions:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Ncbi Official Symbol:
GHR
Additional Names:
GHR, GHBP, GH receptor
Protein Accession Number:
P10912
Ncbi Gene Id Number:
2690
Background:
Growth hormone receptor (GHR) is also known as somatotropin receptor, growth hormone-binding protein (GHBR), which belongs to the type I cytokine receptor family or Type 1 subfamily. GHR contains one fibronectin type-III domain. GHR / GHBR is expressed in various tissues with high expression in liver and skeletal muscle. The soluble form (GHBP) is produced by phorbol ester-promoted proteolytic cleavage at the cell surface (shedding) by ADAM17/TACE. GHR is receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway. The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.
Background Reference 1:
Duquesnoy P., et al., 1994, EMBO J. 13:1386-1395.
Background Reference 2:
Urbanek M., et al., 1993, J. Biol. Chem. 268:19025-19032.

FOR RESEARCH USE ONLY

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Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

96-350

List Size:
0.05 mg

List Price:

$463.00

Datasheet
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