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Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using HDAC8 (Phospho-Ser39).
Immunofluorescence staining of methanol-fixed HeLa cells using HDAC8 (Phospho-Ser39).
Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using HDAC8 (Phospho-Ser39).

HDAC8 (phospho Ser39) Antibody

CATALOG NUMBER: 79-160

Clonality:
Polyclonal
Tested Applications:
IF, IHC
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
HDAC8 (Phospho-Ser39) antibody was raised against a peptide sequence around phosphorylation site of serine 39 (R-A-S (p) -M-V) derived from Human HDAC8.
Conjugate:
Unconjugated
Tested Applications:
IF, IHC
Application Note:
Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200
Specificity:
This antibody detects endogenous level of HDAC8 only when phosphorylated at serine 39.
Predicted Molecular Weight:
42 kDa
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Clonality:
Polyclonal
Physical State:
Liquid
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Storage Conditions:
Store antibody at -20°C for up to one year.
Ncbi Official Symbol:
HDAC8
Additional Names:
HD8, WTS, RPD3, CDA07, CDLS5, MRXS6, HDACL1, MAPKAPK1A, RSK1, HD8, HDA8
Protein Accession Number:
NP_001159890.1
Protein Gi Number:
262073088
Ncbi Gene Id Number:
55869
Background:
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by HDAC8 gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene.
Background Reference 1:
Lee H, et al. (2004) Mol Cell Biol. 24 (2): 765-773.

FOR RESEARCH USE ONLY

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Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

79-160

List Size:
0.1 mg

List Price:

$376.00

Datasheet
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