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Heregulin-B1 Recombinant Protein

CATALOG NUMBER: 40-518

Specifications
source-species:
E. coli
Species:
Human
source-species:
E. coli
Recombinant Protein Sequence:
SHLVKCAEKE KTFCVNGGEC FMVKDLSNPS RYLCKCPNEF TGDRCQNYVM ASFYKHLGIE FMEAE
Biological Activity:
The ED50 was determined by the dose-dependent stimulation of the proliferation of human MCF-7 cells is ≤ 0.5 ng/mL, corresponding to a specific activity of ≥ 2 x 106 units/mg.
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin level is less than 0.1 ng per μg (1EU/μg).
physical-state:
Lyophilized
Storage Conditions:
The lyophilized Heregulin-B1 recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted GDF-2 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, exposing Heregulin-B1 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
Ncbi Official Symbol:
NRG1
Additional Names:
GGF, HGL, HRG, NDF, ARIA, GGF2, HRG1, HRGA, SMDF, MST131, GGF, Pro-neuregulin-1, membrane-bound isoform, Acetylcholine receptor-inducing activity, Pro-NRG1
Protein Accession Number:
NP_001153468.1
Protein Gi Number:
236461846
Ncbi Gene Id Number:
3084
Background:
Neuregulin/Heregulin is a family of structurally related polypeptide growth factors derived from alternatively spliced genes (NRG1, NRG2, NRG3 and NRG4). To date, there are over 14 soluble and transmembrane proteins derived from the NRG1 gene. Proteolytic processing of the extracellular domain of the transmembrane NRG1 isoforms release soluble growth factors. HRG1-B1 contains an Ig domain and an EGF-like domain that is necessary for direct binding to receptor tyrosine kinases erb3 and erb4. This binding induces erb3 and erb4 heterodimerization with erb2, stimulating intrinsic kinase activity, which leads to tyrosine phosphorylation. Although HRG1-B1 biological effects is still unclear, it has been found to promote motility and invasiveness of breast cancer cells which may also involve up-regulation of expression and function of the autocrine motility-promoting factor (AMF). Recombinant human Heregulin-B1 (HRG1-B1) is a 7.5 kDa polypeptide consisting of only the EGF domain of heregulin-B1 (65 amino acid residues).

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
This product is for research use only.

CATALOG NUMBER:

40-518

List Size:
0.05 mg

List Price:

$370.00

Datasheet
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