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Western blot analysis in HepG2 cell line lysates (35ug/lane).
Western blot analysis in HepG2 cell line lysates (35ug/lane).

HLA-DPA1 Antibody

CATALOG NUMBER: 59-441

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
This HLA-DPA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 231-259 amino acids from the C-terminal region of human HLA-DPA1.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
29 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
HLA-DPA1
Additional Names:
HLA class II histocompatibility antigen, DP alpha 1 chain, DP(W3), DP(W4), HLA-SB alpha chain, MHC class II DP3-alpha, MHC class II DPA1, HLA-DPA1, HLA-DP1A, HLASB
Protein Accession Number:
P20036
Protein Gi Number:
122204
Ncbi Gene Id Number:
3113
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
HLA-DPA1 belongs to the HLA class II alpha chainparalogues. This class II molecule is a heterodimer consisting ofan alpha (DPA) and a beta (DPB) chain, both anchored in themembrane. It plays a central role in the immune system bypresenting peptides derived from extracellular proteins. Class IImolecules are expressed in antigen presenting cells (APC: Blymphocytes, dendritic cells, macrophages). The alpha chain isapproximately 33-35 kDa and its gene contains 5 exons. Exon oneencodes the leader peptide, exons 2 and 3 encode the twoextracellular domains, exon 4 encodes the transmembrane domain andthe cytoplasmic tail. Within the DP molecule both the alpha chainand the beta chain contain the polymorphisms specifying the peptidebinding specificities, resulting in up to 4 different molecules.
Background Reference 1:
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Background Reference 2:
Varney, M.D., et al. Diabetes 59(8):2055-2062(2010)
Background Reference 3:
Ovsyannikova, I.G., et al. PLoS ONE(7), E11806 (2010) :
Background Reference 4:
Mychaleckyj, J.C., et al. Clin Trials(1 SUPPL), S75-S87 (2010) :

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

59-441

List Size:
400 ul

List Price:

$495.00

Datasheet
Shipping Info

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