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Western blot analysis of lysate from Raji cell line, using HLA-DRB4 Antibody at 1:1000 at each lane.
Western blot analysis of lysate from Raji cell line, using HLA-DRB4 Antibody at 1:1000 at each lane.

HLA-DRB4 Antibody

CATALOG NUMBER: 57-203

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
This HLA-DRB4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 43-72 amino acids from the N-terminal region of human HLA-DRB4.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
30 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
HLA-DRB4
Additional Names:
HLA class II histocompatibility antigen, DR beta 4 chain, MHC class II antigen DRB4, HLA-DRB4
Protein Accession Number:
P13762
Protein Gi Number:
281371554
Ncbi Gene Id Number:
3126
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
HLA-DRB4 belongs to the HLA class II beta chainparalogues. This class II molecule is a heterodimer consisting ofan alpha (DRA) and a beta (DRB) chain, both anchored in themembrane. It plays a central role in the immune system bypresenting peptides derived from extracellular proteins. Class IImolecules are expressed in antigen presenting cells (APC: Blymphocytes, dendritic cells, macrophages). The beta chain isapproximately 26-28 kDa and its gene contains 6 exons. Exon oneencodes the leader peptide, exons 2 and 3 encode the twoextracellular domains, exon 4 encodes the transmembrane domain andexon 5 encodes the cytoplasmic tail. Within the DR molecule thebeta chain contains all the polymorphisms specifying the peptidebinding specificities. Typing for these polymorphisms is routinelydone for bone marrow and kidney transplantation. DRB1 is expressedat a level five times higher than its paralogues DRB3, DRB4 andDRB5. The presence of DRB4 is linked with allelic variants of DRB1,otherwise it is omitted. There are 4 related pseudogenes: DRB2,DRB6, DRB7, DRB8 and DRB9.
Background Reference 1:
Awa, W.L., et al. Eur. J. Endocrinol. 163(1):97-104(2010)
Background Reference 2:
Christiansen, O.B., et al. J. Reprod. Immunol. 85(1):9-14(2010)
Background Reference 3:
Amoli, M.M., et al. Dis. Markers 28(1):49-53(2010)
Background Reference 4:
Gomez-Tortosa, E., et al. Dement Geriatr Cogn Disord 30(1):8-11(2010)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

57-203

List Size:
400 ul

List Price:

$495.00

Datasheet
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