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Western blot analysis in WiDr cell line lysates (35ug/lane).
Western blot analysis in WiDr cell line lysates (35ug/lane).

HMGCL Antibody

CATALOG NUMBER: 58-337

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Monkey
Immunogen:
This HMGCL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 161-190 amino acids from the Central region of human HMGCL.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
34 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
HMGCL
Additional Names:
Hydroxymethylglutaryl-CoA lyase, mitochondrial, HL, HMG-CoA lyase, 3-hydroxy-3-methylglutarate-CoA lyase, HMGCL
Protein Accession Number:
P35914
Protein Gi Number:
24418852
Ncbi Gene Id Number:
3155
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
HMGCL belongs to the HMG-CoAlyase family. It is a mitochondrial enzyme that catalyzes the finalstep of leucine degradation and plays a key role in ketone bodyformation. Mutations in this gene are associated with HMG-CoA lyasedeficiency. Alternatively spliced transcript variants encodingdifferent isoforms have been found for this gene. [provided byRefSeq].
Background Reference 1:
Fu, Z., et al. J. Biol. Chem. 285(34):26341-26349(2010)
Background Reference 2:
Pierron, S., et al. Arch Pediatr 17(1):10-13(2010)
Background Reference 3:
Menao, S., et al. Hum. Mutat. 30 (3), E520-E529 (2009) :
Background Reference 4:
Lin, W.D., et al. Clin. Chim. Acta 401 (1-2), 33-36 (2009) :

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

58-337

List Size:
400 ul

List Price:

$495.00

Datasheet
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