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Western blot analysis in HL-60 cell line lysates (35ug/lane).
Western blot analysis in HL-60 cell line lysates (35ug/lane).

HTR2C Antibody

CATALOG NUMBER: 57-337

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
This HTR2C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 253-282 amino acids from the Central region of human HTR2C.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
52 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
HTR2C
Additional Names:
5-hydroxytryptamine receptor 2C, 5-HT-2C, 5-HT2C, 5-HTR2C, 5-hydroxytryptamine receptor 1C, 5-HT-1C, 5-HT1C, Serotonin receptor 2C, HTR2C, HTR1C
Protein Accession Number:
P28335
Protein Gi Number:
112816
Ncbi Gene Id Number:
3358
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter,elicits a wide array of physiological effects by binding to severalreceptor subtypes, including the 5-HT2 family ofseven-transmembrane-spanning, G-protein-coupled receptors, whichactivate phospholipase C and D signaling pathways. This geneencodes the 2C subtype of serotonin receptor and its mRNA issubject to multiple RNA editing events, where genomically encodedadenosine residues are converted to inosines. RNA editing ispredicted to alter amino acids within the second intracellular loopof the 5-HT2C receptor and generate receptor isoforms that differin their ability to interact with G proteins and the activation ofphospholipase C and D signaling cascades, thus modulatingserotonergic neurotransmission in the central nervous system.Studies in humans have reported abnormalities in patterns of 5-HT2Cediting in depressed suicide victims.
Background Reference 1:
Gregoor, J.G., et al. Psychiatr. Genet. 20(6):311-316(2010)
Background Reference 2:
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Background Reference 3:
Kiezebrink, K., et al. World J. Biol. Psychiatry 11(6):824-833(2010)
Background Reference 4:
Risselada, A.J., et al. Pharmacogenomics J. (2010) In press :

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

57-337

List Size:
400 ul

List Price:

$495.00

Datasheet
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