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Recombinant Human Atrophin-1 interacting protein 4/ITCH protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue.
Recombinant Human Atrophin-1 interacting protein 4/ITCH protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue.

Human Atrophin-1 Interacting Protein 4/ITCH Recombinant Protein (86-068)

CATALOG NUMBER: 86-068

Tested Applications:
Bioactivity Test, ELISA, Immunogen, SDS-PAGE, WB
Specifications
source-species:
E. coli
Species:
Human
source-species:
E. coli
Recombinant Protein Sequence:
Ser2-Glu903
Fusion Tag:
NO-Tag
Tested Applications:
Bioactivity Test, ELISA, Immunogen, SDS-PAGE, WB
Application Note:
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity Test
Predicted Molecular Weight:
102.67 KDa
Purity:
≥ 90% as determined by reducing SDS-PAGE.
Endotoxin:
Please contact us for more information.
physical-state:
Lyophilized
Buffer:
0.22 μm filtered solution of PBS, pH 7.4.
Storage Conditions:
Store at -70°C.This product is stable at ≤ -70°C for up to 1 year from the date of receipt. For optimal storage, aliquot into smaller quantities after centrifugation and store at recommended temperature. Avoid repeated freeze-thaw cycles.
Additional Names:
ITCH, E3 ubiquitin-protein ligase Itchy homolog, Itch, EC:2.3.2.26, Atrophin-1-interacting protein 4, AIP4, HECT-type E3 ubiquitin transferase Itchy homolog, NFE2-associated polypeptide 1, NAPP1
Protein Accession Number:
NP_001244066.1
Ncbi Gene Id Number:
83737
Background:
ITCH, also called atrophin-1 interacting protein 4 (AIP4), is a HECT-type E3 ubiquitin ligase. It contains an N-terminal Ca-dependent phospholipid-binding C2 domain, four WW domains, and a C-terminal HECT domain. Mice deficient in ITCH protein display many autoimmune-like disease characteristics such as lymphoproliferation in the spleen and lymph nodes. More than a dozen of substrates of ITCH have been identified including p63, p73 and Notch1. The ligase may be responsible for ubiquitinating proteins with K29-, K48-, and/or K63-linked ubiquitin chains.

FOR RESEARCH USE ONLY

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Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

86-068

List Size:
0.05 mg

List Price:

$700.00

Datasheet
Shipping Info

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