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Recombinant Human B7-H6/NCR3LG1 Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue.
Immobilized Human NCR3LG1 (Catalog: 85-415) at 2 μg/mL (100 μL/well) can bind Mouse NCR3 (Catalog: 84-961) with a linear range of 0.03-46 ng/mL.
Recombinant Human B7-H6/NCR3LG1 Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue.

Human B7-H6/NCR3LG1 Recombinant Protein (85-415)

CATALOG NUMBER: 85-415

Tested Applications:
Bioactivity Test, ELISA, Immunogen, SDS-PAGE, WB
Specifications
source-species:
HEK293 cells
Species:
Human
source-species:
HEK293 cells
Recombinant Protein Sequence:
Asp25-Ser262
Fusion Tag:
C-His
Tested Applications:
Bioactivity Test, ELISA, Immunogen, SDS-PAGE, WB
Application Note:
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity Test
Predicted Molecular Weight:
27.51 kDa
Biological Activity:
Measured by its binding ability in a functional ELISA.Immobilized Human NCR3LG1 at 2 μg/mL (100 μL/well) can bind Mouse NCR3 with a linear range of 0.03-46 ng/mL.
Purity:
≥ 90 % as determined by SDS-PAGE.
Endotoxin:
< 1 EU/μg of the protein by LAL method.
physical-state:
Lyophilized
Buffer:
Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.
Storage Conditions:
Store at -20°C.Store the lyophilized protein at -20°C to -80 °C up to 1 year from the date of receipt.
After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.
Additional Names:
B7-H6,NCR3LG1,B7 Homolog 6,NCR3LG1
Protein Accession Number:
NP_001189368.1
Ncbi Gene Id Number:
374383
Background:
Natural cytotoxicity triggering receptor 3 ligand 1(B7-H6) is a glycosylated member of the B7 family of immune costimulatory proteins. Mature human B7-H6 consists of a 238 amino acid (aa) extracellular domain (ECD) that contains one Ig-like V domain and one Ig-like C1 domain, a 21 aa transmembrane segment, and a 171 aa cytoplasmic domain that contains one ITIM, one SH2, and one SH3 motif. Both of the Ig-like domains carry N-linked glycosylation. The Ig-like V domain mediates 1:1 stoichiometric binding of B7-H6 to NKp30 expressed on NK cells. It does not show binding to NKp44, NKp46, or NKG2D. Ligation of NKp30 by B7-H6 induces NK cell activation and target cell cytolysis. B7-H6 is expressed on a wide range of hematopoietic, carcinoma, and melanoma tumor cells, which is consistent with the detection of NKp30 binding sites on many tumors.

FOR RESEARCH USE ONLY

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Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

85-415

List Size:
0.01 mg, 0.05 mg

List Price:

Price range: $126.00 through $280.00

Datasheet
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