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Recombinant Human FcRn/FCGRT&B2M Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue.
Immobilized Human FCGRT&B2M at 5μg/mL (100 μL/well) can bind biotinylated human IgG1 with a linear range of 1-6μg/mL.
Immobilized Trastuzumab on COOH Chip, can bind Human FCGRT&B2M Heterodimer Protein with an affinity constant of 0.22 μM as determined in a SPR assay (OpenSPR).
Recombinant Human FcRn/FCGRT&B2M Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue.

Human FcRn/FCGRT&B2M Recombinant Protein (85-194)

CATALOG NUMBER: 85-194

Tested Applications:
Bioactivity Test, ELISA, Immunogen, SDS-PAGE, WB
Specifications
source-species:
HEK293 cells
Species:
Human
source-species:
HEK293 cells
Fusion Tag:
C-His(FCGRT)&No tag(B2M)
Tested Applications:
Bioactivity Test, ELISA, Immunogen, SDS-PAGE, WB
Application Note:
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity Test
Predicted Molecular Weight:
30.38 kDa(FCGRT), 11.73 kDa(B2M)
Biological Activity:
1.Measured by its binding ability in a functional ELISA. Immobilized Human FCGRT&B2M at 5 μg/mL (100 μL/well) can bind biotinylated human IgG1 with a linear range of 1-6μg/mL.
2.Immobilized Trastuzumab on COOH Chip can bind Human FCGRT&B2M Heterodimer Protein with an affinity constant of 0.22 μM as determined in a SPR assay (OpenSPR).
Purity:
≥ 95 % as determined by SDS-PAGE.
Endotoxin:
< 0.1 EU/μg of the protein by LAL method.
physical-state:
Lyophilized
Buffer:
Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.Contact us for customized product form or formulation.
Storage Conditions:
Store at -20°C.Store the lyophilized protein at -20°C to -80 °C up to 1 year from the date of receipt.
After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.
Additional Names:
FCRN
Protein Accession Number:
NP_004098.1
Ncbi Gene Id Number:
2217/567
Background:
FCGRT & B2M heterodimer protein (FcRn complex) consist of two subunits: p51 (equivalent to FCGRT), and p14 (equivalent to beta-2-microglobulin), and forms an MHC class I-like heterodimer. Fc fragment of IgG, receptor, transporter, alpha (FCGRT) binds to the Fc region of monomeric immunoglobulins gamma and mediates the uptake of IgG from milk. FCGRT possible role in transfer of immunoglobulin G from mother to fetus. Beta-2-microglobulin (B2M) is a component of MHC class I molecules, MHC class I molecules have α1, α2, and α3 proteins which are present on all nucleated cells (excludes red blood cells) and B2M involved in the presentation of peptide antigens to the immune system.

FOR RESEARCH USE ONLY

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Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

85-194

List Size:
0.01 mg, 0.05 mg

List Price:

Price range: $140.00 through $350.00

Datasheet
Shipping Info

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