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Recombinant Human Guanylyl cyclase C/GUCY2C Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue.
Immobilized recombinant Human GUCY2C at 1μg/mL (100 μL/well) can bind GUCY2C Rabbit pAb with a linear range of 1-144ng/mL.
Recombinant Human Guanylyl cyclase C/GUCY2C Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue.

Human Guanylyl cyclase C/GUCY2C Recombinant Protein (85-487)

CATALOG NUMBER: 85-487

Tested Applications:
Bioactivity Test, ELISA, Immunogen, SDS-PAGE, WB
Specifications
source-species:
HEK293 cells
Species:
Human
source-species:
HEK293 cells
Recombinant Protein Sequence:
Ser24-Gln430
Fusion Tag:
C-His&Avi
Tested Applications:
Bioactivity Test, ELISA, Immunogen, SDS-PAGE, WB
Application Note:
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity Test
Predicted Molecular Weight:
48.66 kDa
Biological Activity:
Measured by its binding ability in a functional ELISA. Immobilized Human GUCY2C at 1 μg/mL (100 μL/well) can bind GUCY2C Rabbit pAb with a linear range of 1-144 ng/mL.
Purity:
≥ 95 % as determined by SDS-PAGE.
Endotoxin:
Please contact us for more information.
physical-state:
Lyophilized
Buffer:
Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.
Storage Conditions:
Store at -20°C.Store the lyophilized protein at -20°C to -80 °C up to 1 year from the date of receipt.
After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.
Additional Names:
GUCY2C,DIAR6,GC-C,GUC2C,MECIL,MUCIL,STAR
Protein Accession Number:
NP_004954.2
Ncbi Gene Id Number:
2984
Background:
GUCY2C (Guanylyl Cyclase C), also known as heat-stable enterotoxin receptor, is a type I transmembrane protein of the guanylate cyclase (gc) family that signal by producing cGMP. Guanylate cyclase C (GUCY2C) and its hormones guanylin and uroguanylin have recently emerged as one paracrine axis defending intestinal mucosal integrity against mutational, chemical, and inflammatory injury. GUCY2C murine CAR-T cells recognized and killed human colorectal cancer cells endogenously expressing GUCY2C. Thus, we have identified a human GUCY2C-specific CAR-T cell therapy approach that may be developed for the treatment of GUCY2C-expressing metastatic colorectal cancer. GUCY2C may represent a new target for anti-obesity pharmacotherapy.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

85-487

List Size:
0.05 mg

List Price:

$280.00

Datasheet
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