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Recombinant Human IL-17RA/CD217 Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue.
Recombinant Human IL17RA inhibits IL-17A induced IL-6 secretion by Hela cells. The ED<sub>50</sub> for this effect is 0.02-0.1 μg/mL in the presence of 10 ng/mL recombinant human IL-17A.
Immobilized Recombinant human IL17RA , His Tag at 2 μg/mL (100 μL/well) can bind Recombinant human IL-17A,His Tag with a linear range of 31.25-65ng/mL.
Recombinant Human IL-17RA/CD217 Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue.

Human IL-17RA/CD217 Recombinant Protein (85-051)

CATALOG NUMBER: 85-051

Tested Applications:
Bioactivity Test, ELISA, Immunogen, SDS-PAGE, WB
Specifications
Source Species:
HEK293 cells
Species:
Human
Source Species:
HEK293 cells
Recombinant Protein Sequence:
Leu33-Trp320
Fusion Tag:
C-His
Tested Applications:
Bioactivity Test, ELISA, Immunogen, SDS-PAGE, WB
Application Note:
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity Test
Predicted Molecular Weight:
34.29 kDa
Biological Activity:
1.Measured by its ability to inhibit IL-17A induced IL-6 secretion by Hela cells. The ED50 for this effect is 0.02 0.1 μg/mL in the presence of 10 ng/mL recombinant human IL 17A.
2.Measured by its binding ability in a functional ELISA. Immobilized Recombinant human IL17RA , His Tag at 2 μg/mL (100 μL/well) can bind Recombinant human IL-17A,His Tag with a linear range of 31.25-65 ng/mL.
Purity:
≥ 95 % as determined by SDS-PAGE.
Endotoxin:
< 0.1 EU/μg of the protein by LAL method.
Physical State:
Lyophilized
Buffer:
Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.Contact us for customized product form or formulation.
Storage Conditions:
Store at -20°C.Store the lyophilized protein at -20°C to -80 °C up to 1 year from the date of receipt.
After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.
Additional Names:
CANDF5, CD217, CDw217, IL-17RA, IL17R, IMD51, hIL-17R,IL17RA,CD217,CDw217,IL-17RA,IL17R,IMD51,hIL-17R
Protein Accession Number:
NP_055154.3
Ncbi Gene Id Number:
23765
Background:
Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. This transmembrane protein (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure.

FOR RESEARCH USE ONLY

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Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

85-051

List Size:
0.01 mg, 0.05 mg

List Price:

Price range: $98.00 through $210.00

Datasheet
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