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Recombinant Human Mature GDNF Protein was determined by SDS-PAGE under reducing (R) and non-reducing (NR) conditions.
Measured in a cell proliferation assay using SH-SY5Y cells. The ED<sub>50</sub> for this effect is 1.82-7.26 ng/mL in the presence of Recombinant Human GFR alpha -1 (Catalog # 85-942), corresponding to a specific activity of 1.38×10<sup>5</sup> ~5.49×10<sup>5</sup> units/mg.
Recombinant Human Mature GDNF Protein was determined by SDS-PAGE under reducing (R) and non-reducing (NR) conditions.

Human Mature GDNF Recombinant Protein (85-141)

CATALOG NUMBER: 85-141

Tested Applications:
Bioactivity Test, ELISA, Immunogen, SDS-PAGE, WB
Specifications
Source Species:
E. coli
Species:
Human
Source Species:
E. coli
Recombinant Protein Sequence:
Ser78-Ile211
Fusion Tag:
NO-Tag
Tested Applications:
Bioactivity Test, ELISA, Immunogen, SDS-PAGE, WB
Application Note:
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity Test
Predicted Molecular Weight:
15.07 kDa
Biological Activity:
Measured in a cell proliferation assay using SH-SY5Y cells. The ED50 for this effect is 1.82-7.26 ng/mL in the presence of Recombinant Human GFR alpha -1, corresponding to a specific activity of 1.38×105 ~5.49×105 units/mg.
Purity:
≥ 95 % as determined by SDS-PAGE.
Endotoxin:
< 0.01 EU/μg of the protein by LAL method
Physical State:
Lyophilized
Buffer:
Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.
Storage Conditions:
Store at -20°C.Store the lyophilized protein at -20°C to -80 °C up to 1 year from the date of receipt.
After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.
Additional Names:
GDNF, Glial cell line-derived neurotrophic factor, hGDNF, Astrocyte-derived trophic factor, ATF
Protein Accession Number:
P39905
Ncbi Gene Id Number:
2668
Background:
Glial cell line-derived neurotrophic factor(GDNF) is an important member of the GDNF family of ligands(GFL). The GDNF family of ligands is comprised by four neurotrophic factors: glial cell line-derived neurotrophic factor (GDNF), neurturin (NRTN), artemin (ARTN), and persephin (PSPN). It has been found that GFLs play a role in a number of biological processes including cell survival, neurite outgrowth, cell differentiation and cell migration. As the founding member, GDNF plays a key role in the promotion of the survival of dopaminergic neurons. GDNF is a highly conserved neurotrophic factor. The recombinant form of this protein also promotes the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. GDNF also regulates kidney development and spermatogenesis, and it affects alcohol consumption. It has been shown that GDNF results in two Parkinson's disease clinical trial and in a number of animal trials. It has been taken as a po

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Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

85-141

List Size:
0.01 mg, 0.05 mg

List Price:

Price range: $210.00 through $490.00

Datasheet
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