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Recombinant Human Pro-neuregulin-1/NRG1 (Beta1) Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue.
Recombinant Human Pro-neuregulin-1/NRG1 (Beta1) stimulates serum-free cell proliferation assay using MCF-7 human breast cancer cells. The ED<sub>50</sub> for this effect is typically 0.62-2.48 ng/mL, corresponding to a specific activity of 4.03×10<sup>5</sup>~1.61×10<sup>6</sup> units/mg.
Recombinant Human Pro-neuregulin-1/NRG1 (Beta1) Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue.

Human Pro-neuregulin-1/NRG1 (Beta1) Recombinant Protein (85-822)

CATALOG NUMBER: 85-822

Tested Applications:
Bioactivity Test, ELISA, Immunogen, SDS-PAGE, WB
Specifications
source-species:
E. coli
Species:
Human
source-species:
E. coli
Recombinant Protein Sequence:
Thr 176-Lys 246
Fusion Tag:
No-Tag
Tested Applications:
Bioactivity Test, ELISA, Immunogen, SDS-PAGE, WB
Application Note:
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity Test
Predicted Molecular Weight:
8.06 kDa
Biological Activity:
Measured in a serum-free cell proliferation assay using MCF-7 human breast cancer cells. The ED50 for this effect is typically 0.62-2.48 ng/mL, corresponding to a specific activity of 4.03×105~1.61×106 units/mg.
Purity:
≥ 90 % as determined by SDS-PAGE.
Endotoxin:
< 1 EU/μg of the protein by LAL method.
physical-state:
Lyophilized
Buffer:
Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.
Storage Conditions:
Store at -20°C.Store the lyophilized protein at -20°C to -80 °C up to 1 year from the date of receipt.
After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.
Additional Names:
GGF; HGL; HRG; NDF; ARIA; GGF2; HRG1; HRGA; SMDF; MST131; MSTP131; NRG1-IT2;Pro-neuregulin-1;NRG1(Beta1)
Protein Accession Number:
NP_039250.2
Ncbi Gene Id Number:
3084
Background:
neuregulin-1 (heregulin-1, NRG1) is a member of neuregulin family, which is comprised of four genes thatencode a large number of secreted or membrane-bound isoforms. All family members share an EGF-likedomain that interacts with the ErbB family of tyrosine kinase receptors. NRG1 isoforms can be classified intotype I, type II and type III isoforms. NRG1 directs ligand for ERBB3 and ERBB4 tyrosine kinase receptors,concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylationand activation of the ERBB receptors. NRG proteins show distinct spatial and temporal expression patterns andplay important roles during development of both the nervous system and the heart.

FOR RESEARCH USE ONLY

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Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

85-822

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $196.00 through $448.00

Datasheet
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