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Recombinant Human R-spondin-2/RSPO2 Protein was determined by SDS-PAGE under reducing (R)
Measured by its ability to induce Topflash reporter activity in HEK293T human embryonic kidney cells. The ED<sub>50</sub> for this effect is 0.72-2.88 ng/mL in the presence of 5 ng/mL Recombinant Mouse Wnt-3a,corresponding to a specific activity of 3.47×10<sup>5</sup>~1.39×10<sup>6</sup> units/mg.
Recombinant Human R-spondin-2/RSPO2 Protein was determined by SDS-PAGE under reducing (R)

Human R-spondin-2/RSPO2 Recombinant Protein (86-060)

CATALOG NUMBER: 86-060

Tested Applications:
Bioactivity Test, ELISA, Immunogen, SDS-PAGE, WB
Specifications
source-species:
HEK293 cells
Species:
Human
source-species:
HEK293 cells
Recombinant Protein Sequence:
Ala32-Gly205
Fusion Tag:
C-hFC
Tested Applications:
Bioactivity Test, ELISA, Immunogen, SDS-PAGE, WB
Application Note:
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity Test
Predicted Molecular Weight:
47.66 kDa
Biological Activity:
Measured by its ability to induce Topflash reporter activity in HEK293T human embryonic kidney cells. The ED50 for this effect is 0.72-2.88 ng/mL in the presence of 5 ng/mL Recombinant Mouse Wnt-3a,corresponding to a specific activity of 3.47×105~1.39×106 units/mg.
Purity:
≥ 90 % as determined by SDS-PAGE.
Endotoxin:
< 0.01 EU/μg of the protein by LAL method
physical-state:
Lyophilized
Buffer:
Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.
Storage Conditions:
Store at -20°C.Store the lyophilized protein at -20°C to -80 °C up to 1 year from the date of receipt.
After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.
Additional Names:
R-spondin-2, Roof plate-specific spondin-2, hRspo2,RSPO2, UNQ9384/PRO34209
Protein Accession Number:
Q6UXX9
Ncbi Gene Id Number:
340419
Background:
R-spondins are secretory proteins localized in the endoplasmic reticulum and Golgi bodies and are processed through the secretory pathway. The RSPO family comprises four proteins, i.e., R-spondin 1-4, which are important secreted regulators of the Wnt/尾-catenin and Wnt/PCP signaling pathway and govern various functions and are involved in vital cellular processes such as stem cell renewal, morphogenesis and, tumorigenesis. Among the R-spondin family, R-spondin-2, is a key protein that regulates ligand-dependent 尾-catenin signaling. And it has been reported to play a pivotal role in myogenesis, osteoblast differentiation, and limb specification during embryonic development.

FOR RESEARCH USE ONLY

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Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

86-060

List Size:
0.01 mg, 0.05 mg

List Price:

Price range: $210.00 through $490.00

Datasheet
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