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Recombinant Human TNFSF15/TL1 Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue.
Immobilized Human TNFSF15 Protein at 5 μg/mL (100 μL/well) can bind DCR3 with a linear range of 0.12-6.98 ng/mL.
Recombinant Human TNFSF15 induce apoptosis of TF-1 human erythroleukemic cells. The ED<sub>50</sub> for this effect is 52.1-208.5 ng/mL, corresponding to a specific activity of 4.79×10<sup>3</sup>~1.92×10<sup>4</sup> units/mg.
Recombinant Human TNFSF15/TL1 Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue.

Human TNFSF15/TL1 Recombinant Protein (84-840)

CATALOG NUMBER: 84-840

Tested Applications:
Bioactivity Test, ELISA, Immunogen, SDS-PAGE, WB
Specifications
source-species:
E. coli
Species:
Human
source-species:
E. coli
Recombinant Protein Sequence:
Leu72-Leu251
Fusion Tag:
No tag
Tested Applications:
Bioactivity Test, ELISA, Immunogen, SDS-PAGE, WB
Application Note:
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity Test
Predicted Molecular Weight:
20.47 kDa
Biological Activity:
1.Measured by its binding ability in a functional ELISA. Immobilized Human TNFSF15 Protein at 5 μg/mL (100 μL/well) can bind DCR3 with a linear range of 0.12-6.98 ng/mL.
2.Measured by its ability to induce apoptosis of TF-1 human erythroleukemic cells. The ED50 for this effect is 52.1-208.5 ng/mL, corresponding to a specific activity of 4.79×103~1.92×104 units/mg.
Purity:
≥ 90 % as determined by SDS-PAGE.
Endotoxin:
< 1 EU/μg of the protein by LAL method.
physical-state:
Lyophilized
Buffer:
Lyophilized from a 0.22 μm filtered solution of 20mM Tris, 50mM NaCl, 5% glycerol, pH 8.0.Contact us for customized product form or formulation.
Storage Conditions:
Store at -20°C.Store the lyophilized protein at -20°C to -80 °C up to 1 year from the date of receipt.
After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.
Additional Names:
TNFSF15,TL1,TL1A,TNLG1B,VEGI,VEGI192A
Protein Accession Number:
NP_005109.2
Ncbi Gene Id Number:
9966
Background:
The protein is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

84-840

List Size:
0.01 mg, 0.05 mg

List Price:

Price range: $140.00 through $350.00

Datasheet
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