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Recombinant Human TNFSF9/4-1BB Ligand Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue.
Immobilized recombinant human TNFSF9 at 2 μg/mL (100 μL/well) can bind recombinant human TNFRSF9 with a linear range of 40-100ng/mL.
Immobilized Human TNFSF9/4-1BB at 2 μg/mL (100 μL/well) can bind Human TNFRSF9/4-1BB/CD137 with a linear range of 0.1-5.8 ng/mL.
Recombinant Human TNFSF9/4-1BB Ligand Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue.

Human TNFSF9/4-1BB Ligand Recombinant Protein (84-846)

CATALOG NUMBER: 84-846

Tested Applications:
Bioactivity Test, ELISA, Immunogen, SDS-PAGE, WB
Specifications
source-species:
E. coli
Species:
Human
source-species:
E. coli
Recombinant Protein Sequence:
Arg71-Glu254
Fusion Tag:
C-His
Tested Applications:
Bioactivity Test, ELISA, Immunogen, SDS-PAGE, WB
Application Note:
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity Test
Predicted Molecular Weight:
20.28 kDa
Biological Activity:
1.Measured by its binding ability in a functional ELISA. Immobilized recombinant human TNFSF9 at 2 μg/mL (100 μL/well) can bind recombinant human TNFRSF9 with a linear range of 40-100 ng/mL.
2.Measured by its binding ability in a functional ELISA. Immobilized Human TNFSF9/4-1BB at 2 μg/mL (100 μL/well) can bind Human TNFRSF9/4-1BB/CD137 with a linear range of 0.1-5.8 ng/mL.
Purity:
≥ 95 % as determined by SDS-PAGE.
Endotoxin:
< 0.1 EU/μg of the protein by LAL method.
physical-state:
Lyophilized
Buffer:
Lyophilized from a 0.22 μm filtered solution of 50mM Tris, 150mM NaCl, pH 8.0.Contact us for customized product form or formulation.
Storage Conditions:
Store at -20°C.Store the lyophilized protein at -20°C to -80 °C up to 1 year from the date of receipt.
After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.
Additional Names:
4-1BB-L, CD137L, TNLG5A,TNFSF9,CD137L,TNLG5A
Protein Accession Number:
NP_003802.1
Ncbi Gene Id Number:
8744
Background:
The protein is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.

FOR RESEARCH USE ONLY

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Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

84-846

List Size:
0.01 mg, 0.05 mg

List Price:

Price range: $126.00 through $280.00

Datasheet
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