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Recombinant Human Trk-A/NTRK1 Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue.
Recombinant Human TrkA inhibit NGF-induced proliferation of TF-1 human erythroleukemic cells. The ED<sub>50</sub> for this effect is typically 12-48 ng/mL in the presence of 10 ng/ml of recombinant human NGF.
Recombinant Human Trk-A/NTRK1 Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue.

Human Trk-A/NTRK1 Recombinant Protein (84-873)

CATALOG NUMBER: 84-873

Tested Applications:
Bioactivity Test, ELISA, Immunogen, SDS-PAGE, WB
Specifications
source-species:
HEK293 cells
Species:
Human
source-species:
HEK293 cells
Recombinant Protein Sequence:
Ala33-Glu407
Fusion Tag:
C-hFc&His
Tested Applications:
Bioactivity Test, ELISA, Immunogen, SDS-PAGE, WB
Application Note:
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity Test
Predicted Molecular Weight:
68.30 kDa
Biological Activity:
Measured by its ability to inhibit NGF-induced proliferation of TF-1 human erythroleukemic cells. The ED50 for this effect is typically 12-48 ng/mL in the presence of 10 ng/mL of recombinant human NGF.
Purity:
≥ 95 % as determined by SDS-PAGE.
Endotoxin:
< 0.1 EU/μg of the protein by LAL method.
physical-state:
Lyophilized
Buffer:
Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.Contact us for customized product form or formulation.
Storage Conditions:
Store at -20°C.Store the lyophilized protein at -20°C to -80 °C up to 1 year from the date of receipt.
After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.
Additional Names:
MTC, TRK, TRK1, TRKA, Trk-A, p140-TrkA,NTRK1,TRK,TRK1,TRKA,Trk-A,p140-TrkA
Protein Accession Number:
NP_001012331.1
Ncbi Gene Id Number:
4914
Background:
This protein is a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

84-873

List Size:
0.01 mg, 0.05 mg

List Price:

Price range: $126.00 through $280.00

Datasheet
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