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Huntington Protein Antibody

CATALOG NUMBER: 39-864

Clonality:
Polyclonal
Tested Applications:
ELISA, IHC, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
A synthetic peptide corresponding to the N-terminus.
Conjugate:
Unconjugated
Tested Applications:
ELISA, IHC, WB
Application Note:
ELISA, Western (immuno) blotting, Immunostaining (in testing)
Purification:
Affinity Purified
Clonality:
Polyclonal
Isotype:
IgG
Physical State:
Liquid
Concentration:
batch dependent
Ncbi Official Symbol:
HTT
Additional Names:
HD, IT15, HD
Protein Accession Number:
AAB38240
Protein Gi Number:
296434520
Ncbi Gene Id Number:
3064
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Huntington's disease (HD) is an autosomal dominant neurological disorder caused by a polyglutamine (polyQ) repeat expansion in the huntingtin (Htt) protein. The disease is characterized by neurodegeneration and formation of neuronal intracellular inclusions primarily in the striatum and cortex, leading to personality changes, motor impairment, and dementia. The Huntington’s disease protein is ~350 kDa in size and is localized in the brain.
Background Reference 1:
Huntington's disease: from pathology and genetics to potential therapies. Imarisio S, Carmichael J, Korolchuk V, Chen CW, Saiki S, Rose C, Krishna G, Davies JE, Ttofi E, Underwood BR, Rubinsztein DC. Biochem J. 2008 Jun 1;412(2):191-209
Background Reference 2:
Huntington disease models and human neuropathology: similarities and differences. Vonsattel JP. Acta Neuropathol. 2008 Jan;115(1):55-69
Background Reference 3:
CHD proteins: a diverse family with strong ties. Hall JA, Georgel PT. Biochem Cell Biol. 2007 Aug;85(4):463-76
Background Reference 4:
Characterization and localization of the Huntington disease gene product. André T. Hoogeveen*, Rob Willemsen, Nicolle Meyer, Karien E.de Roolj1, Raymund A.C. Roos2, Gert-Jan B.van Ommen1 and Hans Galjaard, Hum Mol Genet. 1993 Dec;2(12):2069-73

FOR RESEARCH USE ONLY

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Disclaimer:
This product is for research use only.

CATALOG NUMBER:

39-864

List Size:
0.1 mg

List Price:

$626.00

Datasheet
Shipping Info

$65 Standard Overnight flat rate for as many products shipped within the United States.

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