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Western blot analysis in NCI-H460 cell line lysates (35ug/lane).
Western blot analysis in NCI-H460 cell line lysates (35ug/lane).

HUS1 Antibody

CATALOG NUMBER: 58-806

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
This HUS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 199-226 amino acids from the C-terminal region of human HUS1.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
32 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
HUS1
Additional Names:
Checkpoint protein HUS1, hHUS1, HUS1
Protein Accession Number:
O60921
Ncbi Gene Id Number:
3364
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The protein encoded by this gene is a component of anevolutionarily conserved, genotoxin-activated checkpoint complexthat is involved in the cell cycle arrest in response to DNAdamage. This protein forms a heterotrimeric complex with checkpointproteins RAD9 and RAD1. In response to DNA damage, the trimericcomplex interacts with another protein complex consisting ofcheckpoint protein RAD17 and four small subunits of the replicationfactor C (RFC), which loads the combined complex onto thechromatin. The DNA damage induced chromatin binding has been shownto depend on the activation of the checkpoint kinase ATM, and isthought to be an early checkpoint signaling event. [provided byRefSeq].
Background Reference 1:
Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)
Background Reference 2:
Takeishi, Y., et al. Genes Cells 15(7):761-771(2010)
Background Reference 3:
Bai, H., et al. DNA Repair (Amst.) 9(5):478-487(2010)
Background Reference 4:
Guey, L.T., et al. Eur. Urol. 57(2):283-292(2010)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

58-806

List Size:
400 ul

List Price:

$495.00

Datasheet
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